Journal Article

DZNE-2024-00143

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Longitudinal trajectories of cognitive reserve in hypometabolic subtypes of Alzheimer's disease.

Levin, F. (First author)DZNE* ; Grothe, M. J. ; Dyrba, M.DZNE* ; Franzmeier, N. ; Teipel, S. J. (Last author)DZNE* ; Initiative, A. D. N. (Collaboration Author)

2024
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.neurobiolaging.2023.12.003

Abstract: Previous studies have demonstrated resilience to AD-related neuropathology in a form of cognitive reserve (CR). In this study we investigated a relationship between CR and hypometabolic subtypes of AD, specifically the typical and the limbic-predominant subtypes. We analyzed data from 59 Aβ-positive cognitively normal (CN), 221 prodromal Alzheimer's disease (AD) and 174 AD dementia participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) from ADNI and ADNIGO/2 phases. For replication, we analyzed data from 5 Aβ-positive CN, 89 prodromal AD and 43 AD dementia participants from ADNI3. CR was estimated as standardized residuals in a model predicting cognition from temporoparietal grey matter volumes and covariates. Higher CR estimates predicted slower cognitive decline. Typical and limbic-predominant hypometabolic subtypes demonstrated similar baseline CR, but the results suggested a faster decline of CR in the typical subtype. These findings support the relationship between subtypes and CR, specifically longitudinal trajectories of CR. Results also underline the importance of longitudinal analyses in research on CR.

Keyword(s): Humans (MeSH) ; Alzheimer Disease: diagnostic imaging (MeSH) ; Alzheimer Disease: pathology (MeSH) ; Cognitive Reserve (MeSH) ; Brain: diagnostic imaging (MeSH) ; Brain: pathology (MeSH) ; Cognition (MeSH) ; Gray Matter: diagnostic imaging (MeSH) ; Gray Matter: pathology (MeSH) ; Cognitive Dysfunction: pathology (MeSH) ; Alzheimer’s disease ; Alzheimer’s disease ; Alzheimer’s disease ; Alzheimer’s disease ; Cognitive reserve ; FDG-PET ; Mild cognitive impairment ; Prodromal AD ; Subtypes

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Contributing Institute(s):

1. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

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Database coverage:
; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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