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000267982 037__ $$aDZNE-2024-00190
000267982 041__ $$aEnglish
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000267982 1001_ $$avon Zedtwitz, Katharina$$b0
000267982 245__ $$aObsessive-compulsive symptoms and brain lesions compatible with multiple sclerosis.
000267982 260__ $$aWien [u.a.]$$bSpringer$$c2024
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000267982 520__ $$aAutoimmune-mediated obsessive-compulsive disorder (OCD) can occur in multiple sclerosis (MS). Here, a well-studied case study of a patient with OCD and MS-compatible diagnostic findings is presented. The 42-year-old female patient had displayed OCD symptoms for 6 years. Magnetic resonance imaging (MRI) identified several periventricular and one brainstem lesion suggestive of demyelination. Cerebrospinal fluid (CSF) analyses detected an increased white blood cell count, intrathecal immunoglobulin (Ig) G and IgM synthesis, CSF-specific oligoclonal bands, and a positive MRZ reaction. Neopterin was increased, but sarcoidosis was excluded. In the absence of neurological attacks and clues for MRI-based dissemination in time, a radiologically isolated syndrome, the pre-disease stage of MS, was diagnosed. Neurotransmitter measurements of CSF detected reduced serotonin levels. In the absence of visible strategic demyelinating lesions within the cortico-striato-thalamo-cortical circuits, OCD symptoms may relate to reduced intrathecal serotonin levels and mild neuroinflammatory processes. Serotonin abnormalities in MS should be studied further, as they could potentially explain the association between neuroinflammation and mental illnesses.
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000267982 650_7 $$2Other$$aAutoimmune
000267982 650_7 $$2Other$$aCSF
000267982 650_7 $$2Other$$aInflammation
000267982 650_7 $$2Other$$aMultiple sclerosis
000267982 650_7 $$2Other$$aOCD
000267982 650_7 $$2Other$$aRIS
000267982 650_7 $$0333DO1RDJY$$2NLM Chemicals$$aSerotonin
000267982 650_7 $$2NLM Chemicals$$aImmunoglobulin G
000267982 650_2 $$2MeSH$$aFemale
000267982 650_2 $$2MeSH$$aHumans
000267982 650_2 $$2MeSH$$aAdult
000267982 650_2 $$2MeSH$$aMultiple Sclerosis: complications
000267982 650_2 $$2MeSH$$aMultiple Sclerosis: diagnostic imaging
000267982 650_2 $$2MeSH$$aSerotonin
000267982 650_2 $$2MeSH$$aObsessive-Compulsive Disorder: diagnostic imaging
000267982 650_2 $$2MeSH$$aImmunoglobulin G
000267982 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000267982 650_2 $$2MeSH$$aBrain: diagnostic imaging
000267982 650_2 $$2MeSH$$aBrain: pathology
000267982 7001_ $$aTebartz van Elst, Ludger$$b1
000267982 7001_ $$aUrbach, Horst$$b2
000267982 7001_ $$aGroppa, Sergiu$$b3
000267982 7001_ $$aSchiele, Miriam A$$b4
000267982 7001_ $$0P:(DE-2719)2810931$$aPrüss, Harald$$b5$$udzne
000267982 7001_ $$aDomschke, Katharina$$b6
000267982 7001_ $$aStich, Oliver$$b7
000267982 7001_ $$aHannibal, Luciana$$b8
000267982 7001_ $$aEndres, Dominique$$b9
000267982 773__ $$0PERI:(DE-600)1481655-6$$a10.1007/s00702-023-02737-z$$gVol. 131, no. 3, p. 281 - 286$$n3$$p281 - 286$$tJournal of neural transmission$$v131$$x0375-9245$$y2024
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