Journal Article

DZNE-2024-00190

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Obsessive-compulsive symptoms and brain lesions compatible with multiple sclerosis.

von Zedtwitz, K. ; Tebartz van Elst, L. ; Urbach, H. ; Groppa, S. ; Schiele, M. A. ; Prüss, H.DZNE* ; Domschke, K. ; Stich, O. ; Hannibal, L. ; Endres, D.

2024
Springer Wien [u.a.]

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Please use a persistent id in citations: doi:10.1007/s00702-023-02737-z

Abstract: Autoimmune-mediated obsessive-compulsive disorder (OCD) can occur in multiple sclerosis (MS). Here, a well-studied case study of a patient with OCD and MS-compatible diagnostic findings is presented. The 42-year-old female patient had displayed OCD symptoms for 6 years. Magnetic resonance imaging (MRI) identified several periventricular and one brainstem lesion suggestive of demyelination. Cerebrospinal fluid (CSF) analyses detected an increased white blood cell count, intrathecal immunoglobulin (Ig) G and IgM synthesis, CSF-specific oligoclonal bands, and a positive MRZ reaction. Neopterin was increased, but sarcoidosis was excluded. In the absence of neurological attacks and clues for MRI-based dissemination in time, a radiologically isolated syndrome, the pre-disease stage of MS, was diagnosed. Neurotransmitter measurements of CSF detected reduced serotonin levels. In the absence of visible strategic demyelinating lesions within the cortico-striato-thalamo-cortical circuits, OCD symptoms may relate to reduced intrathecal serotonin levels and mild neuroinflammatory processes. Serotonin abnormalities in MS should be studied further, as they could potentially explain the association between neuroinflammation and mental illnesses.

Keyword(s): Female (MeSH) ; Humans (MeSH) ; Adult (MeSH) ; Multiple Sclerosis: complications (MeSH) ; Multiple Sclerosis: diagnostic imaging (MeSH) ; Serotonin (MeSH) ; Obsessive-Compulsive Disorder: diagnostic imaging (MeSH) ; Immunoglobulin G (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Brain: diagnostic imaging (MeSH) ; Brain: pathology (MeSH) ; Autoimmune ; CSF ; Inflammation ; Multiple sclerosis ; OCD ; RIS ; Serotonin ; Immunoglobulin G

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Contributing Institute(s):

1. Autoimmune Encephalopathies (AG Prüß)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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