TY  - JOUR
AU  - von Zedtwitz, Katharina
AU  - Tebartz van Elst, Ludger
AU  - Urbach, Horst
AU  - Groppa, Sergiu
AU  - Schiele, Miriam A
AU  - Prüss, Harald
AU  - Domschke, Katharina
AU  - Stich, Oliver
AU  - Hannibal, Luciana
AU  - Endres, Dominique
TI  - Obsessive-compulsive symptoms and brain lesions compatible with multiple sclerosis.
JO  - Journal of neural transmission
VL  - 131
IS  - 3
SN  - 0375-9245
CY  - Wien [u.a.]
PB  - Springer
M1  - DZNE-2024-00190
SP  - 281 - 286
PY  - 2024
AB  - Autoimmune-mediated obsessive-compulsive disorder (OCD) can occur in multiple sclerosis (MS). Here, a well-studied case study of a patient with OCD and MS-compatible diagnostic findings is presented. The 42-year-old female patient had displayed OCD symptoms for 6 years. Magnetic resonance imaging (MRI) identified several periventricular and one brainstem lesion suggestive of demyelination. Cerebrospinal fluid (CSF) analyses detected an increased white blood cell count, intrathecal immunoglobulin (Ig) G and IgM synthesis, CSF-specific oligoclonal bands, and a positive MRZ reaction. Neopterin was increased, but sarcoidosis was excluded. In the absence of neurological attacks and clues for MRI-based dissemination in time, a radiologically isolated syndrome, the pre-disease stage of MS, was diagnosed. Neurotransmitter measurements of CSF detected reduced serotonin levels. In the absence of visible strategic demyelinating lesions within the cortico-striato-thalamo-cortical circuits, OCD symptoms may relate to reduced intrathecal serotonin levels and mild neuroinflammatory processes. Serotonin abnormalities in MS should be studied further, as they could potentially explain the association between neuroinflammation and mental illnesses.
KW  - Female
KW  - Humans
KW  - Adult
KW  - Multiple Sclerosis: complications
KW  - Multiple Sclerosis: diagnostic imaging
KW  - Serotonin
KW  - Obsessive-Compulsive Disorder: diagnostic imaging
KW  - Immunoglobulin G
KW  - Magnetic Resonance Imaging
KW  - Brain: diagnostic imaging
KW  - Brain: pathology
KW  - Autoimmune (Other)
KW  - CSF (Other)
KW  - Inflammation (Other)
KW  - Multiple sclerosis (Other)
KW  - OCD (Other)
KW  - RIS (Other)
KW  - Serotonin (NLM Chemicals)
KW  - Immunoglobulin G (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:38289491
C2  - pmc:PMC10874305
DO  - DOI:10.1007/s00702-023-02737-z
UR  - https://pub.dzne.de/record/267982
ER  -