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@ARTICLE{vonZedtwitz:267982,
      author       = {von Zedtwitz, Katharina and Tebartz van Elst, Ludger and
                      Urbach, Horst and Groppa, Sergiu and Schiele, Miriam A and
                      Prüss, Harald and Domschke, Katharina and Stich, Oliver and
                      Hannibal, Luciana and Endres, Dominique},
      title        = {{O}bsessive-compulsive symptoms and brain lesions
                      compatible with multiple sclerosis.},
      journal      = {Journal of neural transmission},
      volume       = {131},
      number       = {3},
      issn         = {0375-9245},
      address      = {Wien [u.a.]},
      publisher    = {Springer},
      reportid     = {DZNE-2024-00190},
      pages        = {281 - 286},
      year         = {2024},
      abstract     = {Autoimmune-mediated obsessive-compulsive disorder (OCD) can
                      occur in multiple sclerosis (MS). Here, a well-studied case
                      study of a patient with OCD and MS-compatible diagnostic
                      findings is presented. The 42-year-old female patient had
                      displayed OCD symptoms for 6 years. Magnetic resonance
                      imaging (MRI) identified several periventricular and one
                      brainstem lesion suggestive of demyelination. Cerebrospinal
                      fluid (CSF) analyses detected an increased white blood cell
                      count, intrathecal immunoglobulin (Ig) G and IgM synthesis,
                      CSF-specific oligoclonal bands, and a positive MRZ reaction.
                      Neopterin was increased, but sarcoidosis was excluded. In
                      the absence of neurological attacks and clues for MRI-based
                      dissemination in time, a radiologically isolated syndrome,
                      the pre-disease stage of MS, was diagnosed. Neurotransmitter
                      measurements of CSF detected reduced serotonin levels. In
                      the absence of visible strategic demyelinating lesions
                      within the cortico-striato-thalamo-cortical circuits, OCD
                      symptoms may relate to reduced intrathecal serotonin levels
                      and mild neuroinflammatory processes. Serotonin
                      abnormalities in MS should be studied further, as they could
                      potentially explain the association between
                      neuroinflammation and mental illnesses.},
      keywords     = {Female / Humans / Adult / Multiple Sclerosis: complications
                      / Multiple Sclerosis: diagnostic imaging / Serotonin /
                      Obsessive-Compulsive Disorder: diagnostic imaging /
                      Immunoglobulin G / Magnetic Resonance Imaging / Brain:
                      diagnostic imaging / Brain: pathology / Autoimmune (Other) /
                      CSF (Other) / Inflammation (Other) / Multiple sclerosis
                      (Other) / OCD (Other) / RIS (Other) / Serotonin (NLM
                      Chemicals) / Immunoglobulin G (NLM Chemicals)},
      cin          = {AG Prüß},
      ddc          = {610},
      cid          = {I:(DE-2719)1810003},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38289491},
      pmc          = {pmc:PMC10874305},
      doi          = {10.1007/s00702-023-02737-z},
      url          = {https://pub.dzne.de/record/267982},
}