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001     267982
005     20240225002541.0
024 7 _ |a 10.1007/s00702-023-02737-z
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024 7 _ |a 0022-3026
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024 7 _ |a 0300-9564
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024 7 _ |a 1435-1463
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037 _ _ |a DZNE-2024-00190
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a von Zedtwitz, Katharina
|b 0
245 _ _ |a Obsessive-compulsive symptoms and brain lesions compatible with multiple sclerosis.
260 _ _ |a Wien [u.a.]
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520 _ _ |a Autoimmune-mediated obsessive-compulsive disorder (OCD) can occur in multiple sclerosis (MS). Here, a well-studied case study of a patient with OCD and MS-compatible diagnostic findings is presented. The 42-year-old female patient had displayed OCD symptoms for 6 years. Magnetic resonance imaging (MRI) identified several periventricular and one brainstem lesion suggestive of demyelination. Cerebrospinal fluid (CSF) analyses detected an increased white blood cell count, intrathecal immunoglobulin (Ig) G and IgM synthesis, CSF-specific oligoclonal bands, and a positive MRZ reaction. Neopterin was increased, but sarcoidosis was excluded. In the absence of neurological attacks and clues for MRI-based dissemination in time, a radiologically isolated syndrome, the pre-disease stage of MS, was diagnosed. Neurotransmitter measurements of CSF detected reduced serotonin levels. In the absence of visible strategic demyelinating lesions within the cortico-striato-thalamo-cortical circuits, OCD symptoms may relate to reduced intrathecal serotonin levels and mild neuroinflammatory processes. Serotonin abnormalities in MS should be studied further, as they could potentially explain the association between neuroinflammation and mental illnesses.
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650 _ 7 |a Autoimmune
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650 _ 7 |a CSF
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650 _ 7 |a Inflammation
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650 _ 7 |a Multiple sclerosis
|2 Other
650 _ 7 |a OCD
|2 Other
650 _ 7 |a RIS
|2 Other
650 _ 7 |a Serotonin
|0 333DO1RDJY
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650 _ 7 |a Immunoglobulin G
|2 NLM Chemicals
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Multiple Sclerosis: complications
|2 MeSH
650 _ 2 |a Multiple Sclerosis: diagnostic imaging
|2 MeSH
650 _ 2 |a Serotonin
|2 MeSH
650 _ 2 |a Obsessive-Compulsive Disorder: diagnostic imaging
|2 MeSH
650 _ 2 |a Immunoglobulin G
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Brain: diagnostic imaging
|2 MeSH
650 _ 2 |a Brain: pathology
|2 MeSH
700 1 _ |a Tebartz van Elst, Ludger
|b 1
700 1 _ |a Urbach, Horst
|b 2
700 1 _ |a Groppa, Sergiu
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700 1 _ |a Schiele, Miriam A
|b 4
700 1 _ |a Prüss, Harald
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700 1 _ |a Domschke, Katharina
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700 1 _ |a Stich, Oliver
|b 7
700 1 _ |a Hannibal, Luciana
|b 8
700 1 _ |a Endres, Dominique
|b 9
773 _ _ |a 10.1007/s00702-023-02737-z
|g Vol. 131, no. 3, p. 281 - 286
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|t Journal of neural transmission
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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