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000268468 0247_ $$2doi$$a10.1002/eji.202350519
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000268468 041__ $$aEnglish
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000268468 1001_ $$0P:(DE-2719)9001774$$aMueller, Sophie$$b0$$eFirst author$$udzne
000268468 245__ $$aWhole blood stimulation as a tool for studying the human immune system.
000268468 260__ $$aWeinheim$$bWiley-VCH$$c2024
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000268468 520__ $$aThe human immune system is best accessible via tissues and organs not requiring major surgical intervention, such as blood. In many circumstances, circulating immune cells correlate with an individual's health state and give insight into physiological and pathophysiological processes. Stimulating whole blood ex vivo is a powerful tool to investigate immune responses. In the context of clinical research, the applications of whole blood stimulation include host immunity, disease characterization, diagnosis, treatment, and drug development. Here, we summarize different setups and readouts of whole blood assays and discuss applications for preclinical research and clinical practice. Finally, we propose combining whole blood stimulation with high-throughput technologies, such as single-cell RNA-sequencing, to comprehensively analyze the human immune system for the identification of biomarkers, therapeutic interventions as well as companion diagnostics.
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000268468 650_7 $$2Other$$aWhole blood ⋅ Ex vivo stimulation ⋅ Functional immune assay ⋅ Precision medicine
000268468 650_7 $$2Other$$aWhole blood ⋅ Ex vivo stimulation ⋅ Functional immune assay ⋅ Precision medicine
000268468 650_7 $$2Other$$aWhole blood ⋅ Ex vivo stimulation ⋅ Functional immune assay ⋅ Precision medicine
000268468 650_2 $$2MeSH$$aBlood
000268468 650_2 $$2MeSH$$aHumans
000268468 650_2 $$2MeSH$$aImmune System
000268468 693__ $$0EXP:(DE-2719)PRECISE-20190321$$5EXP:(DE-2719)PRECISE-20190321$$ePlatform for Single Cell Genomics and Epigenomics at DZNE  University of Bonn$$x0
000268468 7001_ $$0P:(DE-2719)9000629$$aKroeger, Charlotte$$b1$$eFirst author$$udzne
000268468 7001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim L$$b2
000268468 7001_ $$0P:(DE-2719)2812913$$aAschenbrenner, Anna C$$b3$$eLast author
000268468 773__ $$0PERI:(DE-600)1491907-2$$a10.1002/eji.202350519$$gVol. 54, no. 2, p. 2350519$$n2$$p2350519$$tEuropean journal of immunology$$v54$$x0014-2980$$y2024
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