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000268731 1001_ $$0P:(DE-2719)2812099$$aMocellin, Petra$$b0$$udzne
000268731 245__ $$aA septal-ventral tegmental area circuit drives exploratory behavior.
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000268731 520__ $$aTo survive, animals need to balance their exploratory drive with their need for safety. Subcortical circuits play an important role in initiating and modulating movement based on external demands and the internal state of the animal; however, how motivation and onset of locomotion are regulated remain largely unresolved. Here, we show that a glutamatergic pathway from the medial septum and diagonal band of Broca (MSDB) to the ventral tegmental area (VTA) controls exploratory locomotor behavior in mice. Using a self-supervised machine learning approach, we found an overrepresentation of exploratory actions, such as sniffing, whisking, and rearing, when this projection is optogenetically activated. Mechanistically, this role relies on glutamatergic MSDB projections that monosynaptically target a subset of both glutamatergic and dopaminergic VTA neurons. Taken together, we identified a glutamatergic basal forebrain to midbrain circuit that initiates locomotor activity and contributes to the expression of exploration-associated behavior.
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000268731 650_7 $$2Other$$aVTA
000268731 650_7 $$2Other$$abehavioral quantification
000268731 650_7 $$2Other$$aexploration
000268731 650_7 $$2Other$$aglutamatergic neurons
000268731 650_7 $$2Other$$alocomotion
000268731 650_7 $$2Other$$amedial septum
000268731 650_2 $$2MeSH$$aMice
000268731 650_2 $$2MeSH$$aAnimals
000268731 650_2 $$2MeSH$$aVentral Tegmental Area: physiology
000268731 650_2 $$2MeSH$$aExploratory Behavior
000268731 650_2 $$2MeSH$$aDopaminergic Neurons: metabolism
000268731 650_2 $$2MeSH$$aMotivation
000268731 7001_ $$0P:(DE-2719)2812474$$aBarnstedt, Oliver$$b1$$udzne
000268731 7001_ $$0P:(DE-2719)2812453$$aLuxem, Kevin$$b2$$udzne
000268731 7001_ $$0P:(DE-2719)2810255$$aKaneko, Hiroshi$$b3$$udzne
000268731 7001_ $$aVieweg, Silvia$$b4
000268731 7001_ $$0P:(DE-2719)2813276$$aHenschke, Julia$$b5$$udzne
000268731 7001_ $$0P:(DE-2719)2811426$$aDalügge, Dennis$$b6$$udzne
000268731 7001_ $$0P:(DE-2719)2811225$$aFuhrmann, Falko$$b7$$udzne
000268731 7001_ $$aKarpova, Anna$$b8
000268731 7001_ $$0P:(DE-2719)2813669$$aPakan, Janelle M P$$b9$$udzne
000268731 7001_ $$0P:(DE-2719)2811905$$aKreutz, Michael R$$b10$$udzne
000268731 7001_ $$0P:(DE-2719)9002580$$aMikulovic, Sanja$$b11$$udzne
000268731 7001_ $$0P:(DE-2719)2810375$$aRemy, Stefan$$b12$$eLast author$$udzne
000268731 773__ $$0PERI:(DE-600)2001944-0$$a10.1016/j.neuron.2023.12.016$$gVol. 112, no. 6, p. 1020 - 1032.e7$$n6$$p1020 - 1032.e7$$tNeuron$$v112$$x0896-6273$$y2024
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