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@ARTICLE{Mocellin:268731,
      author       = {Mocellin, Petra and Barnstedt, Oliver and Luxem, Kevin and
                      Kaneko, Hiroshi and Vieweg, Silvia and Henschke, Julia and
                      Dalügge, Dennis and Fuhrmann, Falko and Karpova, Anna and
                      Pakan, Janelle M P and Kreutz, Michael R and Mikulovic,
                      Sanja and Remy, Stefan},
      title        = {{A} septal-ventral tegmental area circuit drives
                      exploratory behavior.},
      journal      = {Neuron},
      volume       = {112},
      number       = {6},
      issn         = {0896-6273},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DZNE-2024-00307},
      pages        = {1020 - 1032.e7},
      year         = {2024},
      abstract     = {To survive, animals need to balance their exploratory drive
                      with their need for safety. Subcortical circuits play an
                      important role in initiating and modulating movement based
                      on external demands and the internal state of the animal;
                      however, how motivation and onset of locomotion are
                      regulated remain largely unresolved. Here, we show that a
                      glutamatergic pathway from the medial septum and diagonal
                      band of Broca (MSDB) to the ventral tegmental area (VTA)
                      controls exploratory locomotor behavior in mice. Using a
                      self-supervised machine learning approach, we found an
                      overrepresentation of exploratory actions, such as sniffing,
                      whisking, and rearing, when this projection is
                      optogenetically activated. Mechanistically, this role relies
                      on glutamatergic MSDB projections that monosynaptically
                      target a subset of both glutamatergic and dopaminergic VTA
                      neurons. Taken together, we identified a glutamatergic basal
                      forebrain to midbrain circuit that initiates locomotor
                      activity and contributes to the expression of
                      exploration-associated behavior.},
      keywords     = {Mice / Animals / Ventral Tegmental Area: physiology /
                      Exploratory Behavior / Dopaminergic Neurons: metabolism /
                      Motivation / VTA (Other) / behavioral quantification (Other)
                      / exploration (Other) / glutamatergic neurons (Other) /
                      locomotion (Other) / medial septum (Other)},
      cin          = {AG Remy / AG Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)1013006 / I:(DE-2719)5000006},
      pnm          = {351 - Brain Function (POF4-351) / 353 - Clinical and Health
                      Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-351 / G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38266645},
      doi          = {10.1016/j.neuron.2023.12.016},
      url          = {https://pub.dzne.de/record/268731},
}