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000268773 041__ $$aEnglish
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000268773 1001_ $$aLuib, Elena$$b0
000268773 245__ $$aReduced tear fluid production in neurological diseases: a cohort study in 708 patients.
000268773 260__ $$aHeidelberg$$bSpringer$$c2024
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000268773 520__ $$aTear fluid (TF) production is an important component of normal ocular function. It is regulated by parasympathetic and sympathetic innervation. Because parasympathetic nerve fibers originate in the brainstem, pathology in this brain region may affect TF production. For example, a reduction in TF production has been described in patients with Parkinson's disease (PD).TF was collected at one center from 772 individuals, 708 of which were patients with different neurological diseases, and 64 healthy controls. Wetting lengths (WL) were recorded using Schirmer test strips with a collection time of 10 min.WL correlated negatively with age and was significantly reduced in subgroups of patients with neurodegenerative diseases (NDDs) (PD, Amyotrophic lateral sclerosis (ALS), other motor neuron diseases (MNDs)), as well as inflammatory/autoimmune/infectious central nervous system (CNS) diseases and vascular CNS diseases (VCDs), even if corrected for age or sex. While temperature had a significant negative effect on TF production, other environmental factors, such as hours of sunlight and humidity, did not.WL was altered in many neurological diseases compared to healthy controls. Most importantly, we observed a reduction of WL in NDDs, independent of age or sex. This study highlights the potential of WL as an easily obtainable parameter and suggests functional alterations in the autonomic innervation in various neurological disorders.
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000268773 650_7 $$2Other$$aNeurodegeneration
000268773 650_7 $$2Other$$aNeurological diseases
000268773 650_7 $$2Other$$aTear fluid
000268773 650_7 $$2Other$$aWetting length
000268773 650_2 $$2MeSH$$aHumans
000268773 650_2 $$2MeSH$$aCohort Studies
000268773 650_2 $$2MeSH$$aNervous System Diseases
000268773 650_2 $$2MeSH$$aMotor Neuron Disease
000268773 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: pathology
000268773 650_2 $$2MeSH$$aBrain: pathology
000268773 650_2 $$2MeSH$$aParkinson Disease
000268773 7001_ $$aDemleitner, Antonia F$$b1
000268773 7001_ $$aCordts, Isabell$$b2
000268773 7001_ $$aWestenberg, Erica$$b3
000268773 7001_ $$aRau, Petra$$b4
000268773 7001_ $$aPürner, Dominik$$b5
000268773 7001_ $$aHaller, Bernhard$$b6
000268773 7001_ $$0P:(DE-2719)2812561$$aLingor, Paul$$b7$$eLast author
000268773 773__ $$0PERI:(DE-600)1421299-7$$a10.1007/s00415-023-12104-3$$gVol. 271, no. 4, p. 1824 - 1836$$n4$$p1824 - 1836$$tJournal of neurology$$v271$$x0367-004X$$y2024
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