Journal Article

DZNE-2024-00317

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Reduced tear fluid production in neurological diseases: a cohort study in 708 patients.

Luib, E. ; Demleitner, A. F. ; Cordts, I. ; Westenberg, E. ; Rau, P. ; Pürner, D. ; Haller, B. ; Lingor, P. (Last author)DZNE*

2024
Springer Heidelberg

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Please use a persistent id in citations: doi:10.1007/s00415-023-12104-3

Abstract: Tear fluid (TF) production is an important component of normal ocular function. It is regulated by parasympathetic and sympathetic innervation. Because parasympathetic nerve fibers originate in the brainstem, pathology in this brain region may affect TF production. For example, a reduction in TF production has been described in patients with Parkinson's disease (PD).TF was collected at one center from 772 individuals, 708 of which were patients with different neurological diseases, and 64 healthy controls. Wetting lengths (WL) were recorded using Schirmer test strips with a collection time of 10 min.WL correlated negatively with age and was significantly reduced in subgroups of patients with neurodegenerative diseases (NDDs) (PD, Amyotrophic lateral sclerosis (ALS), other motor neuron diseases (MNDs)), as well as inflammatory/autoimmune/infectious central nervous system (CNS) diseases and vascular CNS diseases (VCDs), even if corrected for age or sex. While temperature had a significant negative effect on TF production, other environmental factors, such as hours of sunlight and humidity, did not.WL was altered in many neurological diseases compared to healthy controls. Most importantly, we observed a reduction of WL in NDDs, independent of age or sex. This study highlights the potential of WL as an easily obtainable parameter and suggests functional alterations in the autonomic innervation in various neurological disorders.

Keyword(s): Humans (MeSH) ; Cohort Studies (MeSH) ; Nervous System Diseases (MeSH) ; Motor Neuron Disease (MeSH) ; Amyotrophic Lateral Sclerosis: pathology (MeSH) ; Brain: pathology (MeSH) ; Parkinson Disease (MeSH) ; Neurodegeneration ; Neurological diseases ; Tear fluid ; Wetting length

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Contributing Institute(s):

1. Clinical Research (Munich) (Clinical Research (Munich))

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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