TY  - JOUR
AU  - Chen, Xiaoli
AU  - Wei, Ziwei
AU  - Wolbers, Thomas
TI  - Repetition Suppression Reveals Cue-specific Spatial Representations for Landmarks and Self-motion Cues in Human Retrosplenial Cortex.
JO  - eNeuro
VL  - 11
IS  - 4
SN  - 2373-2822
CY  - Washington, DC
PB  - Soc.
M1  - DZNE-2024-00351
SP  - ENEURO.0294-23.2024
PY  - 2024
AB  -  The efficient use of various spatial cues within a setting is crucial for successful navigation. Two fundamental forms of spatial navigation, landmark-based and self-motion-based, engage distinct cognitive mechanisms. The question of whether these modes invoke shared or separate spatial representations in the brain remains unresolved. While nonhuman animal studies have yielded inconsistent results, human investigation is limited. In our previous work (Chen et al., 2019), we introduced a novel spatial navigation paradigm utilizing ultra-high field fMRI to explore neural coding of positional information. We found that different entorhinal subregions in the right hemisphere encode positional information for landmarks and self-motion cues. The present study tested the generalizability of our previous finding with a modified navigation paradigm. Although we did not replicate our previous finding in the entorhinal cortex, we identified adaptation-based allocentric positional codes for both cue types in the retrosplenial cortex (RSC), which were not confounded by the path to the spatial location. Crucially, the multi-voxel patterns of these spatial codes differed between the cue types, suggesting cue-specific positional coding. The parahippocampal cortex exhibited positional coding for self-motion cues, which was not dissociable from path length. Finally, the brain regions involved in successful navigation differed from our previous study, indicating overall distinct neural mechanisms recruited in our two studies. Taken together, the current findings demonstrate cue-specific allocentric positional coding in the human RSC in the same navigation task for the first time and that spatial representations in the brain are contingent on specific experimental conditions.
KW  - Humans
KW  - Animals
KW  - Cues
KW  - Gyrus Cinguli
KW  - Entorhinal Cortex
KW  - Brain
KW  - Spatial Navigation
KW  - Space Perception
KW  - adaptation (Other)
KW  - entorhinal cortex (Other)
KW  - landmark (Other)
KW  - path integration (Other)
KW  - retrosplenial cortex (Other)
KW  - spatial navigation (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC11007318
C6  - pmid:38519127
DO  - DOI:10.1523/ENEURO.0294-23.2024
UR  - https://pub.dzne.de/record/268847
ER  -