Journal Article (Review Article)

DZNE-2024-00450

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Modulation of AMPA receptor function by auxiliary subunits

Monyer, H. ; Engelhardt, J. (Last author)DZNE*

2015
Spektrum Akademischer Verlag Berlin

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Please use a persistent id in citations: doi:10.1007/s13295-015-0005-z

Abstract: AMPA receptors are ionotropic glutamate receptors that mediate the majority of fast excitatory transmission in the central nervous system. Their function depends not only on the composition of the subunits GluA1-4, but also on the interaction with auxiliary subunits. Several auxiliary subunits have been identified in proteomic analyses over the last years and we are beginning to understand the complex control of these proteins on physiological properties and membrane-transport of AMPA receptors. Auxiliary subunits such as TARPs, cornichons, and CKAMP44 influence receptor localization on the cell membrane, modulate receptor gating, and play a role for synaptic short-term and long-term plasticity.

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Contributing Institute(s):

1. Synaptic Signalling and Neurodegeneration (AG Engelhardt)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

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Database coverage:
NCBI Molecular Biology Database

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