Journal Article

DZNE-2024-00494

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit.

Peng, Y. ; Bjelde, A. ; Aceituno, P. V. ; Mittermaier, F. X. ; Planert, H. ; Grosser, S. ; Onken, J. ; Faust, K. ; Kalbhenn, T. ; Simon, M. ; Radbruch, H. ; Fidzinski, P.DZNE* ; Schmitz, D.DZNE* ; Alle, H. ; Holtkamp, M. ; Vida, I. ; Grewe, B. F. ; Geiger, J. R. P.

2024
Assoc. Washington, DC

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Please use a persistent id in citations: doi:10.1126/science.adg8828

Abstract: The computational capabilities of neuronal networks are fundamentally constrained by their specific connectivity. Previous studies of cortical connectivity have mostly been carried out in rodents; whether the principles established therein also apply to the evolutionarily expanded human cortex is unclear. We studied network properties within the human temporal cortex using samples obtained from brain surgery. We analyzed multineuron patch-clamp recordings in layer 2-3 pyramidal neurons and identified substantial differences compared with rodents. Reciprocity showed random distribution, synaptic strength was independent from connection probability, and connectivity of the supragranular temporal cortex followed a directed and mostly acyclic graph topology. Application of these principles in neuronal models increased dimensionality of network dynamics, suggesting a critical role for cortical computation.

Keyword(s): Animals (MeSH) ; Humans (MeSH) ; Nerve Net: physiology (MeSH) ; Nerve Net: ultrastructure (MeSH) ; Pyramidal Cells: physiology (MeSH) ; Pyramidal Cells: ultrastructure (MeSH) ; Rodentia (MeSH) ; Synapses: physiology (MeSH) ; Synapses: ultrastructure (MeSH) ; Temporal Lobe: physiology (MeSH) ; Patch-Clamp Techniques (MeSH)

Note: ISSN 1095-9203 not unique: **3 hits**.

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Contributing Institute(s):

1. Network Dysfunction (AG Schmitz)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2024

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Chemical Reactions ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 50 ; Index Chemicus ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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