000269438 001__ 269438
000269438 005__ 20240826165954.0
000269438 0247_ $$2doi$$a10.1371/journal.pone.0299939.t001
000269438 037__ $$aDZNE-2024-00535
000269438 1001_ $$0P:(DE-2719)9001827$$aLiebscher, Maxie$$b0$$udzne
000269438 245__ $$aDataset: Descriptive data of the matched sample (n = 130).
000269438 260__ $$bPLOS ONE$$c2024
000269438 3367_ $$2BibTeX$$aMISC
000269438 3367_ $$0PUB:(DE-HGF)32$$2PUB:(DE-HGF)$$aDataset$$bdataset$$mdataset$$s1715677578_2123
000269438 3367_ $$026$$2EndNote$$aChart or Table
000269438 3367_ $$2DataCite$$aDataset
000269438 3367_ $$2ORCID$$aDATA_SET
000269438 3367_ $$2DINI$$aResearchData
000269438 520__ $$aBackground: Participation in multimodal leisure activities, such as playing a musical instrument, may be protective against brain aging and dementia in older adults (OA). Potential neuroprotective correlates underlying musical activity remain unclear.Objective: This cross-sectional study investigated the association between lifetime musical activity and resting-state functional connectivity (RSFC) in three higher-order brain networks: the Default Mode, Fronto-Parietal, and Salience networks.Methods: We assessed 130 cognitively unimpaired participants (≥ 60 years) from the baseline cohort of the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Lifetime musical activity was operationalized by the self-reported participation in musical instrument playing across early, middle, and late life stages using the Lifetime of Experiences Questionnaire (LEQ). Participants who reported musical activity during all life stages (n = 65) were compared to controls who were matched on demographic and reserve characteristics (including education, intelligence, socioeconomic status, self-reported physical activity, age, and sex) and never played a musical instrument (n = 65) in local (seed-to-voxel) and global (within-network and between-network) RSFC patterns using pre-specified network seeds.Results: Older participants with lifetime musical activity showed significantly higher local RSFC between the medial prefrontal cortex (Default Mode Network seed) and temporal as well as frontal regions, namely the right temporal pole and the right precentral gyrus extending into the superior frontal gyrus, compared to matched controls. There were no significant group differences in global RSFC within or between the three networks.Conclusion: We show that playing a musical instrument during life relates to higher RSFC of the medial prefrontal cortex with distant brain regions involved in higher-order cognitive and motor processes. Preserved or enhanced functional connectivity could potentially contribute to better brain health and resilience in OA with a history in musical activity.Trial registration: German Clinical Trials Register (DRKS00007966, 04/05/2015).
000269438 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000269438 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x1
000269438 588__ $$aDataset connected to DataCite
000269438 7001_ $$0P:(DE-2719)9001684$$aDell Orco, Andrea$$b1$$udzne
000269438 7001_ $$0P:(DE-HGF)0$$aDoll-Lee, Johanna$$b2
000269438 7001_ $$0P:(DE-2719)2811351$$aBürger, Katharina$$b3$$udzne
000269438 7001_ $$0P:(DE-HGF)0$$aDechent, Peter$$b4
000269438 7001_ $$0P:(DE-2719)9000543$$aEwers, Michael$$b5$$udzne
000269438 7001_ $$0P:(DE-2719)2811326$$aFließbach, Klaus$$b6$$udzne
000269438 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b7$$udzne
000269438 7001_ $$0P:(DE-HGF)0$$aHetzer, Stefan$$b8
000269438 7001_ $$0P:(DE-2719)9002557$$aJanowitz, Daniel$$b9$$udzne
000269438 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b10$$udzne
000269438 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b11$$udzne
000269438 7001_ $$0P:(DE-HGF)0$$aLüsebrink, Falk$$b12
000269438 7001_ $$0P:(DE-2719)9001516$$aMunk, Matthias$$b13$$udzne
000269438 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b14$$udzne
000269438 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b15$$udzne
000269438 7001_ $$0P:(DE-2719)9000703$$aPreis, Lukas$$b16$$udzne
000269438 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b17$$udzne
000269438 7001_ $$0P:(DE-2719)9001808$$aRauchmann, Boris Stephan$$b18$$udzne
000269438 7001_ $$0P:(DE-HGF)0$$aRostamzadeh, Ayda$$b19
000269438 7001_ $$0P:(DE-2719)2812341$$aRoy, Nina$$b20$$udzne
000269438 7001_ $$0P:(DE-2719)9001147$$aScheffler, Katja$$b21
000269438 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b22$$udzne
000269438 7001_ $$0P:(DE-2719)2814326$$aSchott, Björn$$b23$$udzne
000269438 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b24$$udzne
000269438 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike Jakob$$b25
000269438 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b26$$udzne
000269438 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b27$$udzne
000269438 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b28$$udzne
000269438 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b29$$udzne
000269438 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b30$$udzne
000269438 7001_ $$0P:(DE-2719)2810395$$aRöske, Sandra$$b31$$udzne
000269438 7001_ $$0P:(DE-2719)2814122$$aWirth, Miranka$$b32$$udzne
000269438 773__ $$a10.1371/journal.pone.0299939.t001
000269438 7870_ $$0DZNE-2024-00526$$aLiebscher, Maxie et.al.$$dSan Francisco, California, US : PLOS, 2024$$iRelatedTo$$tShort communication: Lifetime musical activity and resting-state functional connectivity in cognitive networks.
000269438 909CO $$ooai:pub.dzne.de:269438$$pVDB
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001827$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001684$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811351$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000543$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811326$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811614$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002557$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b9$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810394$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b10$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000055$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b11$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001516$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b13$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812234$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b14$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811024$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b15$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000703$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b16$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811122$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b17$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001808$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b18$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812341$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b20$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812035$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b22$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2814326$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b23$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811324$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b24$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000026$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b26$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811317$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b27$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000032$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b28$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000005$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b29$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000057$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b30$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810395$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b31$$kDZNE
000269438 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2814122$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b32$$kDZNE
000269438 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000269438 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x1
000269438 9141_ $$y2024
000269438 9201_ $$0I:(DE-2719)1710011$$kAG Wirth$$lBrain Resilience$$x0
000269438 9201_ $$0I:(DE-2719)1111015$$kClinical Research (Munich)$$lClinical Research (Munich)$$x1
000269438 9201_ $$0I:(DE-2719)1510100$$kAG Teipel$$lClinical Dementia Research (Rostock /Greifswald)$$x2
000269438 9201_ $$0I:(DE-2719)5000006$$kAG Düzel$$lClinical Neurophysiology and Memory$$x3
000269438 9201_ $$0I:(DE-2719)1011101$$kPatient Studies Bonn$$lPatient Studies Bonn$$x4
000269438 9201_ $$0I:(DE-2719)1210000$$kAG Gasser$$lParkinson Genetics$$x5
000269438 9201_ $$0I:(DE-2719)5000022$$kAG Dichgans$$lVascular Cognitive Impairment & Post-Stroke Dementia$$x6
000269438 9201_ $$0I:(DE-2719)5000000$$kAG Peters$$lBiomarker-Assisted Early Detection of Dementias$$x7
000269438 9201_ $$0I:(DE-2719)1011305$$kAG Schneider$$lTranslational Dementia Research (Bonn)$$x8
000269438 9201_ $$0I:(DE-2719)1011103$$kAG Spottke$$lClinical Research Platform (CRP)$$x9
000269438 9201_ $$0I:(DE-2719)1811005$$kAG Endres$$lInterdisciplinary Dementia Research$$x10
000269438 9201_ $$0I:(DE-2719)5000007$$kAG Priller$$lTranslational Neuropsychiatry$$x11
000269438 9201_ $$0I:(DE-2719)1110008$$kAG Simons$$lMolecular Neurobiology$$x12
000269438 9201_ $$0I:(DE-2719)1410002$$kAG Fischer$$lEpigenetics and Systems Medicine in Neurodegenerative Diseases$$x13
000269438 9201_ $$0I:(DE-2719)1011102$$kAG Jessen$$lClinical Alzheimer’s Disease Research$$x14
000269438 9201_ $$0I:(DE-2719)1410006$$kAG Wiltfang$$lMolecular biomarkers for predictive diagnostics of neurodegenerative diseases$$x15
000269438 980__ $$adataset
000269438 980__ $$aVDB
000269438 980__ $$aI:(DE-2719)1710011
000269438 980__ $$aI:(DE-2719)1111015
000269438 980__ $$aI:(DE-2719)1510100
000269438 980__ $$aI:(DE-2719)5000006
000269438 980__ $$aI:(DE-2719)1011101
000269438 980__ $$aI:(DE-2719)1210000
000269438 980__ $$aI:(DE-2719)5000022
000269438 980__ $$aI:(DE-2719)5000000
000269438 980__ $$aI:(DE-2719)1011305
000269438 980__ $$aI:(DE-2719)1011103
000269438 980__ $$aI:(DE-2719)1811005
000269438 980__ $$aI:(DE-2719)5000007
000269438 980__ $$aI:(DE-2719)1110008
000269438 980__ $$aI:(DE-2719)1410002
000269438 980__ $$aI:(DE-2719)1011102
000269438 980__ $$aI:(DE-2719)1410006
000269438 980__ $$aUNRESTRICTED