Home > Publications Database > Dataset: Descriptive data of the matched sample (n = 130).
 
Dataset DZNE-2024-00535
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Dataset: Descriptive data of the matched sample (n = 130).

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2024
PLOS ONE

PLOS ONE () [10.1371/journal.pone.0299939.t001]

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Abstract: Background: Participation in multimodal leisure activities, such as playing a musical instrument, may be protective against brain aging and dementia in older adults (OA). Potential neuroprotective correlates underlying musical activity remain unclear.Objective: This cross-sectional study investigated the association between lifetime musical activity and resting-state functional connectivity (RSFC) in three higher-order brain networks: the Default Mode, Fronto-Parietal, and Salience networks.Methods: We assessed 130 cognitively unimpaired participants (≥ 60 years) from the baseline cohort of the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Lifetime musical activity was operationalized by the self-reported participation in musical instrument playing across early, middle, and late life stages using the Lifetime of Experiences Questionnaire (LEQ). Participants who reported musical activity during all life stages (n = 65) were compared to controls who were matched on demographic and reserve characteristics (including education, intelligence, socioeconomic status, self-reported physical activity, age, and sex) and never played a musical instrument (n = 65) in local (seed-to-voxel) and global (within-network and between-network) RSFC patterns using pre-specified network seeds.Results: Older participants with lifetime musical activity showed significantly higher local RSFC between the medial prefrontal cortex (Default Mode Network seed) and temporal as well as frontal regions, namely the right temporal pole and the right precentral gyrus extending into the superior frontal gyrus, compared to matched controls. There were no significant group differences in global RSFC within or between the three networks.Conclusion: We show that playing a musical instrument during life relates to higher RSFC of the medial prefrontal cortex with distant brain regions involved in higher-order cognitive and motor processes. Preserved or enhanced functional connectivity could potentially contribute to better brain health and resilience in OA with a history in musical activity.Trial registration: German Clinical Trials Register (DRKS00007966, 04/05/2015).

Contributing Institute(s):
  1. Brain Resilience (AG Wirth)
  2. Clinical Research (Munich) (Clinical Research (Munich))
  3. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)
  4. Clinical Neurophysiology and Memory (AG Düzel)
  5. Patient Studies Bonn (Patient Studies Bonn)
  6. Parkinson Genetics (AG Gasser)
  7. Vascular Cognitive Impairment & Post-Stroke Dementia (AG Dichgans)
  8. Biomarker-Assisted Early Detection of Dementias (AG Peters)
  9. Translational Dementia Research (Bonn) (AG Schneider)
  10. Clinical Research Platform (CRP) (AG Spottke)
  11. Interdisciplinary Dementia Research (AG Endres)
  12. Translational Neuropsychiatry (AG Priller)
  13. Molecular Neurobiology (AG Simons)
  14. Epigenetics and Systems Medicine in Neurodegenerative Diseases (AG Fischer)
  15. Clinical Alzheimer’s Disease Research (AG Jessen)
  16. Molecular biomarkers for predictive diagnostics of neurodegenerative diseases (AG Wiltfang)
Research Program(s):
  1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)
  2. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2024
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The record appears in these collections:
Institute Collections > M DZNE > M DZNE-Clinical Research (Munich)
Institute Collections > BN DZNE > BN DZNE-Patient Studies (Bonn)
Document types > Other Resources > Datasets
Institute Collections > GÖ DZNE > GÖ DZNE-AG Wiltfang
Institute Collections > BN DZNE > BN DZNE-AG Schneider
Institute Collections > GÖ DZNE > GÖ DZNE-AG Fischer
Institute Collections > ROS DZNE > ROS DZNE-AG Teipel
Institute Collections > TÜ DZNE > TÜ DZNE-AG Gasser
Institute Collections > BN DZNE > BN DZNE-AG Spottke
Institute Collections > BN DZNE > BN DZNE-AG Jessen
Institute Collections > MD DZNE > MD DZNE-AG Düzel
Institute Collections > M DZNE > M DZNE-AG Dichgans
Institute Collections > DD DZNE > DD DZNE-AG Wirth
Institute Collections > B DZNE > B DZNE-AG Priller
Institute Collections > M DZNE > M DZNE-AG Simons
Institute Collections > B DZNE > B DZNE-AG Peters
Institute Collections > B DZNE > B DZNE-AG Endres
Public records
Publications Database
Linked articles:

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Short communication: Lifetime musical activity and resting-state functional connectivity in cognitive networks.
PLOS ONE 19(5), e0299939 () [10.1371/journal.pone.0299939] OpenAccess  Download fulltext Files  Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

 Record created 2024-05-08, last modified 2024-08-26
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