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@MISC{Liebscher:269438,
      author       = {Liebscher, Maxie and Dell Orco, Andrea and Doll-Lee,
                      Johanna and Bürger, Katharina and Dechent, Peter and Ewers,
                      Michael and Fließbach, Klaus and Glanz, Wenzel and Hetzer,
                      Stefan and Janowitz, Daniel and Kilimann, Ingo and Laske,
                      Christoph and Lüsebrink, Falk and Munk, Matthias and
                      Perneczky, Robert and Peters, Oliver and Preis, Lukas and
                      Priller, Josef and Rauchmann, Boris Stephan and Rostamzadeh,
                      Ayda and Roy, Nina and Scheffler, Katja and Schneider, Anja
                      and Schott, Björn and Spottke, Annika and Spruth, Eike
                      Jakob and Teipel, Stefan and Wiltfang, Jens and Jessen,
                      Frank and Düzel, Emrah and Wagner, Michael and Röske,
                      Sandra and Wirth, Miranka},
      title        = {{D}ataset: {D}escriptive data of the matched sample (n =
                      130).},
      publisher    = {PLOS ONE},
      reportid     = {DZNE-2024-00535},
      year         = {2024},
      abstract     = {Background: Participation in multimodal leisure activities,
                      such as playing a musical instrument, may be protective
                      against brain aging and dementia in older adults (OA).
                      Potential neuroprotective correlates underlying musical
                      activity remain unclear.Objective: This cross-sectional
                      study investigated the association between lifetime musical
                      activity and resting-state functional connectivity (RSFC) in
                      three higher-order brain networks: the Default Mode,
                      Fronto-Parietal, and Salience networks.Methods: We assessed
                      130 cognitively unimpaired participants (≥ 60 years) from
                      the baseline cohort of the DZNE-Longitudinal Cognitive
                      Impairment and Dementia Study (DELCODE) study. Lifetime
                      musical activity was operationalized by the self-reported
                      participation in musical instrument playing across early,
                      middle, and late life stages using the Lifetime of
                      Experiences Questionnaire (LEQ). Participants who reported
                      musical activity during all life stages (n = 65) were
                      compared to controls who were matched on demographic and
                      reserve characteristics (including education, intelligence,
                      socioeconomic status, self-reported physical activity, age,
                      and sex) and never played a musical instrument (n = 65) in
                      local (seed-to-voxel) and global (within-network and
                      between-network) RSFC patterns using pre-specified network
                      seeds.Results: Older participants with lifetime musical
                      activity showed significantly higher local RSFC between the
                      medial prefrontal cortex (Default Mode Network seed) and
                      temporal as well as frontal regions, namely the right
                      temporal pole and the right precentral gyrus extending into
                      the superior frontal gyrus, compared to matched controls.
                      There were no significant group differences in global RSFC
                      within or between the three networks.Conclusion: We show
                      that playing a musical instrument during life relates to
                      higher RSFC of the medial prefrontal cortex with distant
                      brain regions involved in higher-order cognitive and motor
                      processes. Preserved or enhanced functional connectivity
                      could potentially contribute to better brain health and
                      resilience in OA with a history in musical activity.Trial
                      registration: German Clinical Trials Register (DRKS00007966,
                      04/05/2015).},
      cin          = {AG Wirth / Clinical Research (Munich) / AG Teipel / AG
                      Düzel / Patient Studies Bonn / AG Gasser / AG Dichgans / AG
                      Peters / AG Schneider / AG Spottke / AG Endres / AG Priller
                      / AG Simons / AG Fischer / AG Jessen / AG Wiltfang},
      cid          = {I:(DE-2719)1710011 / I:(DE-2719)1111015 /
                      I:(DE-2719)1510100 / I:(DE-2719)5000006 / I:(DE-2719)1011101
                      / I:(DE-2719)1210000 / I:(DE-2719)5000022 /
                      I:(DE-2719)5000000 / I:(DE-2719)1011305 / I:(DE-2719)1011103
                      / I:(DE-2719)1811005 / I:(DE-2719)5000007 /
                      I:(DE-2719)1110008 / I:(DE-2719)1410002 / I:(DE-2719)1011102
                      / I:(DE-2719)1410006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)32},
      doi          = {10.1371/journal.pone.0299939.t001},
      url          = {https://pub.dzne.de/record/269438},
}