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000269678 041__ $$aEnglish
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000269678 1001_ $$aGao, Xiaoyan$$b0
000269678 245__ $$aHuman lung cancer-derived mesenchymal stem cells promote tumor growth and immunosuppression.
000269678 260__ $$aLondon$$bBioMed Central$$c2024
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000269678 520__ $$aThe presence of mesenchymal stem cells has been confirmed in some solid tumors where they serve as important components of the tumor microenvironment; however, their role in cancer has not been fully elucidated. The aim of this study was to investigate the functions of mesenchymal stem cells isolated from tumor tissues of patients with non-small cell lung cancer.Human lung cancer-derived mesenchymal stem cells displayed the typical morphology and immunophenotype of mesenchymal stem cells; they were nontumorigenic and capable of undergoing multipotent differentiation. These isolated cells remarkably enhanced tumor growth when incorporated into systems alongside tumor cells in vivo. Importantly, in the presence of mesenchymal stem cells, the ability of peripheral blood mononuclear cell-derived natural killer and activated T cells to mediate tumor cell destruction was significantly compromised.Collectively, these data support the notion that human lung cancer-derived mesenchymal stem cells protect tumor cells from immune-mediated destruction by inhibiting the antitumor activities of natural killer and T cells.
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000269678 650_7 $$2Other$$aImmunophenotype
000269678 650_7 $$2Other$$aMesenchymal stem cell
000269678 650_7 $$2Other$$aMultipotent differentiation
000269678 650_7 $$2Other$$aNatural killer cell
000269678 650_7 $$2Other$$aNon-small cell lung cancer
000269678 650_7 $$2Other$$aT cell
000269678 650_7 $$2Other$$aTumorigenic
000269678 650_2 $$2MeSH$$aHumans
000269678 650_2 $$2MeSH$$aMesenchymal Stem Cells
000269678 650_2 $$2MeSH$$aLung Neoplasms: immunology
000269678 650_2 $$2MeSH$$aCarcinoma, Non-Small-Cell Lung: immunology
000269678 650_2 $$2MeSH$$aKiller Cells, Natural: immunology
000269678 650_2 $$2MeSH$$aAnimals
000269678 650_2 $$2MeSH$$aMice
000269678 650_2 $$2MeSH$$aT-Lymphocytes: immunology
000269678 650_2 $$2MeSH$$aCell Differentiation
000269678 650_2 $$2MeSH$$aTumor Microenvironment
000269678 650_2 $$2MeSH$$aCell Line, Tumor
000269678 7001_ $$aRen, He$$b1
000269678 7001_ $$aZhang, Zhengrong$$b2
000269678 7001_ $$aCao, Shuai$$b3
000269678 7001_ $$aZhang, Bo$$b4
000269678 7001_ $$aSun, Qiang$$b5
000269678 7001_ $$0P:(DE-2719)9001390$$aMelino, Gerry$$b6$$udzne
000269678 7001_ $$aHuang, Hongyan$$b7
000269678 773__ $$0PERI:(DE-600)2221028-3$$a10.1186/s13062-024-00479-w$$gVol. 19, no. 1, p. 39$$n1$$p39$$tBiology direct$$v19$$x1745-6150$$y2024
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