Journal Article

DZNE-2024-00592

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Human lung cancer-derived mesenchymal stem cells promote tumor growth and immunosuppression.

Gao, X. ; Ren, H. ; Zhang, Z. ; Cao, S. ; Zhang, B. ; Sun, Q. ; Melino, G.DZNE* ; Huang, H.

2024
BioMed Central London

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Please use a persistent id in citations: doi:10.1186/s13062-024-00479-w

Abstract: The presence of mesenchymal stem cells has been confirmed in some solid tumors where they serve as important components of the tumor microenvironment; however, their role in cancer has not been fully elucidated. The aim of this study was to investigate the functions of mesenchymal stem cells isolated from tumor tissues of patients with non-small cell lung cancer.Human lung cancer-derived mesenchymal stem cells displayed the typical morphology and immunophenotype of mesenchymal stem cells; they were nontumorigenic and capable of undergoing multipotent differentiation. These isolated cells remarkably enhanced tumor growth when incorporated into systems alongside tumor cells in vivo. Importantly, in the presence of mesenchymal stem cells, the ability of peripheral blood mononuclear cell-derived natural killer and activated T cells to mediate tumor cell destruction was significantly compromised.Collectively, these data support the notion that human lung cancer-derived mesenchymal stem cells protect tumor cells from immune-mediated destruction by inhibiting the antitumor activities of natural killer and T cells.

Keyword(s): Humans (MeSH) ; Mesenchymal Stem Cells (MeSH) ; Lung Neoplasms: immunology (MeSH) ; Carcinoma, Non-Small-Cell Lung: immunology (MeSH) ; Killer Cells, Natural: immunology (MeSH) ; Animals (MeSH) ; Mice (MeSH) ; T-Lymphocytes: immunology (MeSH) ; Cell Differentiation (MeSH) ; Tumor Microenvironment (MeSH) ; Cell Line, Tumor (MeSH) ; Immunophenotype ; Mesenchymal stem cell ; Multipotent differentiation ; Natural killer cell ; Non-small cell lung cancer ; T cell ; Tumorigenic

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Contributing Institute(s):

1. Synaptic Connectivity and Neurodegeneration (AG Nicotera)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2024

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