TY  - JOUR
AU  - Gao, Xiaoyan
AU  - Ren, He
AU  - Zhang, Zhengrong
AU  - Cao, Shuai
AU  - Zhang, Bo
AU  - Sun, Qiang
AU  - Melino, Gerry
AU  - Huang, Hongyan
TI  - Human lung cancer-derived mesenchymal stem cells promote tumor growth and immunosuppression.
JO  - Biology direct
VL  - 19
IS  - 1
SN  - 1745-6150
CY  - London
PB  - BioMed Central
M1  - DZNE-2024-00592
SP  - 39
PY  - 2024
AB  - The presence of mesenchymal stem cells has been confirmed in some solid tumors where they serve as important components of the tumor microenvironment; however, their role in cancer has not been fully elucidated. The aim of this study was to investigate the functions of mesenchymal stem cells isolated from tumor tissues of patients with non-small cell lung cancer.Human lung cancer-derived mesenchymal stem cells displayed the typical morphology and immunophenotype of mesenchymal stem cells; they were nontumorigenic and capable of undergoing multipotent differentiation. These isolated cells remarkably enhanced tumor growth when incorporated into systems alongside tumor cells in vivo. Importantly, in the presence of mesenchymal stem cells, the ability of peripheral blood mononuclear cell-derived natural killer and activated T cells to mediate tumor cell destruction was significantly compromised.Collectively, these data support the notion that human lung cancer-derived mesenchymal stem cells protect tumor cells from immune-mediated destruction by inhibiting the antitumor activities of natural killer and T cells.
KW  - Humans
KW  - Mesenchymal Stem Cells
KW  - Lung Neoplasms: immunology
KW  - Carcinoma, Non-Small-Cell Lung: immunology
KW  - Killer Cells, Natural: immunology
KW  - Animals
KW  - Mice
KW  - T-Lymphocytes: immunology
KW  - Cell Differentiation
KW  - Tumor Microenvironment
KW  - Cell Line, Tumor
KW  - Immunophenotype (Other)
KW  - Mesenchymal stem cell (Other)
KW  - Multipotent differentiation (Other)
KW  - Natural killer cell (Other)
KW  - Non-small cell lung cancer (Other)
KW  - T cell (Other)
KW  - Tumorigenic (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38755705
C2  - pmc:PMC11097554
DO  - DOI:10.1186/s13062-024-00479-w
UR  - https://pub.dzne.de/record/269678
ER  -