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@ARTICLE{Gao:269678,
      author       = {Gao, Xiaoyan and Ren, He and Zhang, Zhengrong and Cao,
                      Shuai and Zhang, Bo and Sun, Qiang and Melino, Gerry and
                      Huang, Hongyan},
      title        = {{H}uman lung cancer-derived mesenchymal stem cells promote
                      tumor growth and immunosuppression.},
      journal      = {Biology direct},
      volume       = {19},
      number       = {1},
      issn         = {1745-6150},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DZNE-2024-00592},
      pages        = {39},
      year         = {2024},
      abstract     = {The presence of mesenchymal stem cells has been confirmed
                      in some solid tumors where they serve as important
                      components of the tumor microenvironment; however, their
                      role in cancer has not been fully elucidated. The aim of
                      this study was to investigate the functions of mesenchymal
                      stem cells isolated from tumor tissues of patients with
                      non-small cell lung cancer.Human lung cancer-derived
                      mesenchymal stem cells displayed the typical morphology and
                      immunophenotype of mesenchymal stem cells; they were
                      nontumorigenic and capable of undergoing multipotent
                      differentiation. These isolated cells remarkably enhanced
                      tumor growth when incorporated into systems alongside tumor
                      cells in vivo. Importantly, in the presence of mesenchymal
                      stem cells, the ability of peripheral blood mononuclear
                      cell-derived natural killer and activated T cells to mediate
                      tumor cell destruction was significantly
                      compromised.Collectively, these data support the notion that
                      human lung cancer-derived mesenchymal stem cells protect
                      tumor cells from immune-mediated destruction by inhibiting
                      the antitumor activities of natural killer and T cells.},
      keywords     = {Humans / Mesenchymal Stem Cells / Lung Neoplasms:
                      immunology / Carcinoma, Non-Small-Cell Lung: immunology /
                      Killer Cells, Natural: immunology / Animals / Mice /
                      T-Lymphocytes: immunology / Cell Differentiation / Tumor
                      Microenvironment / Cell Line, Tumor / Immunophenotype
                      (Other) / Mesenchymal stem cell (Other) / Multipotent
                      differentiation (Other) / Natural killer cell (Other) /
                      Non-small cell lung cancer (Other) / T cell (Other) /
                      Tumorigenic (Other)},
      cin          = {AG Nicotera},
      ddc          = {570},
      cid          = {I:(DE-2719)5000018},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38755705},
      pmc          = {pmc:PMC11097554},
      doi          = {10.1186/s13062-024-00479-w},
      url          = {https://pub.dzne.de/record/269678},
}