Home > Publications Database > Human lung cancer-derived mesenchymal stem cells promote tumor growth and immunosuppression. > print

001     269678
005     20240809090116.0
024 7 _ |a 10.1186/s13062-024-00479-w
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041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Gao, Xiaoyan
|b 0
245 _ _ |a Human lung cancer-derived mesenchymal stem cells promote tumor growth and immunosuppression.
260 _ _ |a London
|c 2024
|b BioMed Central
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520 _ _ |a The presence of mesenchymal stem cells has been confirmed in some solid tumors where they serve as important components of the tumor microenvironment; however, their role in cancer has not been fully elucidated. The aim of this study was to investigate the functions of mesenchymal stem cells isolated from tumor tissues of patients with non-small cell lung cancer.Human lung cancer-derived mesenchymal stem cells displayed the typical morphology and immunophenotype of mesenchymal stem cells; they were nontumorigenic and capable of undergoing multipotent differentiation. These isolated cells remarkably enhanced tumor growth when incorporated into systems alongside tumor cells in vivo. Importantly, in the presence of mesenchymal stem cells, the ability of peripheral blood mononuclear cell-derived natural killer and activated T cells to mediate tumor cell destruction was significantly compromised.Collectively, these data support the notion that human lung cancer-derived mesenchymal stem cells protect tumor cells from immune-mediated destruction by inhibiting the antitumor activities of natural killer and T cells.
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650 _ 7 |a Immunophenotype
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650 _ 7 |a Mesenchymal stem cell
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650 _ 7 |a Multipotent differentiation
|2 Other
650 _ 7 |a Natural killer cell
|2 Other
650 _ 7 |a Non-small cell lung cancer
|2 Other
650 _ 7 |a T cell
|2 Other
650 _ 7 |a Tumorigenic
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Mesenchymal Stem Cells
|2 MeSH
650 _ 2 |a Lung Neoplasms: immunology
|2 MeSH
650 _ 2 |a Carcinoma, Non-Small-Cell Lung: immunology
|2 MeSH
650 _ 2 |a Killer Cells, Natural: immunology
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Mice
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650 _ 2 |a T-Lymphocytes: immunology
|2 MeSH
650 _ 2 |a Cell Differentiation
|2 MeSH
650 _ 2 |a Tumor Microenvironment
|2 MeSH
650 _ 2 |a Cell Line, Tumor
|2 MeSH
700 1 _ |a Ren, He
|b 1
700 1 _ |a Zhang, Zhengrong
|b 2
700 1 _ |a Cao, Shuai
|b 3
700 1 _ |a Zhang, Bo
|b 4
700 1 _ |a Sun, Qiang
|b 5
700 1 _ |a Melino, Gerry
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700 1 _ |a Huang, Hongyan
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773 _ _ |a 10.1186/s13062-024-00479-w
|g Vol. 19, no. 1, p. 39
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|t Biology direct
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|y 2024
|x 1745-6150
856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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