TY  - JOUR
AU  - Larsen, Frode Kibsgaard
AU  - Baksh, R Asaad
AU  - McGlinchey, Eimear
AU  - Langballe, Ellen Melbye
AU  - Benejam, Bessy
AU  - Beresford-Webb, Jessica
AU  - McCarron, Mary
AU  - Coppus, Antonia
AU  - Falquero, Segolene
AU  - Fortea, Juan
AU  - Levin, Johannes
AU  - Loosli, Sandra V
AU  - Mark, Ruth
AU  - Rebillat, Anne-Sophie
AU  - Zaman, Shahid
AU  - Strydom, Andre
TI  - Age of Alzheimer's disease diagnosis in people with Down syndrome and associated factors: Results from the Horizon 21 European Down syndrome consortium.
JO  - Alzheimer's and dementia
VL  - 20
IS  - 5
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2024-00594
SP  - 3270 - 3280
PY  - 2024
AB  - People with Down syndrome (DS) have high risk of developing Alzheimer's disease (AD). This study examined mean ages of AD diagnosis and associations with co-occurring conditions among adults with DS from five European countries.Data from 1335 people with DS from the Horizon 21 European DS Consortium were used for the analysis.Mean ages of AD diagnosis ranged between 51.4 (SD 7.0) years (United Kingdom) and 55.6 (SD 6.8) years (France). Sleep-related and mental health problems were associated with earlier age of AD diagnosis. The higher number of co-occurring conditions the more likely the person with DS is diagnosed with AD at an earlier age.Mean age of AD diagnosis in DS was relatively consistent across countries. However, co-occurring conditions varied and impacted on age of diagnosis, suggesting that improvements can be made in diagnosing and managing these conditions to delay onset of AD in DS.Mean age of AD diagnosis was relatively consistent between countries Sleep problems and mental health problems were associated with earlier age of AD diagnosis APOE ε4 carriers were diagnosed with AD at an earlier age compared to non-carriers Number of co-occurring conditions was associated with earlier age of AD diagnosis No differences between level of intellectual disability and mean age of AD diagnosis.
KW  - Humans
KW  - Down Syndrome: epidemiology
KW  - Down Syndrome: diagnosis
KW  - Down Syndrome: complications
KW  - Alzheimer Disease: diagnosis
KW  - Alzheimer Disease: epidemiology
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Europe: epidemiology
KW  - Adult
KW  - United Kingdom: epidemiology
KW  - Sleep Wake Disorders: epidemiology
KW  - Sleep Wake Disorders: diagnosis
KW  - Age Factors
KW  - Age of Onset
KW  - France: epidemiology
KW  - Aged
KW  - Comorbidity
KW  - Apolipoprotein E4: genetics
KW  - co‐occurring conditions (Other)
KW  - Alzheimer's disease (Other)
KW  - Down syndrome (Other)
KW  - age of diagnosis (Other)
KW  - co‐occurring conditions (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38506627
C2  - pmc:PMC11095427
DO  - DOI:10.1002/alz.13779
UR  - https://pub.dzne.de/record/269680
ER  -