Journal Article

DZNE-2024-00594

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Age of Alzheimer's disease diagnosis in people with Down syndrome and associated factors: Results from the Horizon 21 European Down syndrome consortium.

Larsen, F. K. ; Baksh, R. A. ; McGlinchey, E. ; Langballe, E. M. ; Benejam, B. ; Beresford-Webb, J. ; McCarron, M. ; Coppus, A. ; Falquero, S. ; Fortea, J. ; Levin, J.DZNE* ; Loosli, S. V. ; Mark, R. ; Rebillat, A.-S. ; Zaman, S. ; Strydom, A.

2024
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.13779

Abstract: People with Down syndrome (DS) have high risk of developing Alzheimer's disease (AD). This study examined mean ages of AD diagnosis and associations with co-occurring conditions among adults with DS from five European countries.Data from 1335 people with DS from the Horizon 21 European DS Consortium were used for the analysis.Mean ages of AD diagnosis ranged between 51.4 (SD 7.0) years (United Kingdom) and 55.6 (SD 6.8) years (France). Sleep-related and mental health problems were associated with earlier age of AD diagnosis. The higher number of co-occurring conditions the more likely the person with DS is diagnosed with AD at an earlier age.Mean age of AD diagnosis in DS was relatively consistent across countries. However, co-occurring conditions varied and impacted on age of diagnosis, suggesting that improvements can be made in diagnosing and managing these conditions to delay onset of AD in DS.Mean age of AD diagnosis was relatively consistent between countries Sleep problems and mental health problems were associated with earlier age of AD diagnosis APOE ε4 carriers were diagnosed with AD at an earlier age compared to non-carriers Number of co-occurring conditions was associated with earlier age of AD diagnosis No differences between level of intellectual disability and mean age of AD diagnosis.

Keyword(s): Humans (MeSH) ; Down Syndrome: epidemiology (MeSH) ; Down Syndrome: diagnosis (MeSH) ; Down Syndrome: complications (MeSH) ; Alzheimer Disease: diagnosis (MeSH) ; Alzheimer Disease: epidemiology (MeSH) ; Male (MeSH) ; Female (MeSH) ; Middle Aged (MeSH) ; Europe: epidemiology (MeSH) ; Adult (MeSH) ; United Kingdom: epidemiology (MeSH) ; Sleep Wake Disorders: epidemiology (MeSH) ; Sleep Wake Disorders: diagnosis (MeSH) ; Age Factors (MeSH) ; Age of Onset (MeSH) ; France: epidemiology (MeSH) ; Aged (MeSH) ; Comorbidity (MeSH) ; Apolipoprotein E4: genetics (MeSH) ; co‐occurring conditions ; Alzheimer's disease ; Down syndrome ; age of diagnosis ; co‐occurring conditions

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Contributing Institute(s):

1. Clinical Neurodegeneration (AG Levin)
2. Clinical Research (Munich) (Clinical Research (Munich))

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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