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@ARTICLE{Larsen:269680,
      author       = {Larsen, Frode Kibsgaard and Baksh, R Asaad and McGlinchey,
                      Eimear and Langballe, Ellen Melbye and Benejam, Bessy and
                      Beresford-Webb, Jessica and McCarron, Mary and Coppus,
                      Antonia and Falquero, Segolene and Fortea, Juan and Levin,
                      Johannes and Loosli, Sandra V and Mark, Ruth and Rebillat,
                      Anne-Sophie and Zaman, Shahid and Strydom, Andre},
      title        = {{A}ge of {A}lzheimer's disease diagnosis in people with
                      {D}own syndrome and associated factors: {R}esults from the
                      {H}orizon 21 {E}uropean {D}own syndrome consortium.},
      journal      = {Alzheimer's and dementia},
      volume       = {20},
      number       = {5},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2024-00594},
      pages        = {3270 - 3280},
      year         = {2024},
      abstract     = {People with Down syndrome (DS) have high risk of developing
                      Alzheimer's disease (AD). This study examined mean ages of
                      AD diagnosis and associations with co-occurring conditions
                      among adults with DS from five European countries.Data from
                      1335 people with DS from the Horizon 21 European DS
                      Consortium were used for the analysis.Mean ages of AD
                      diagnosis ranged between 51.4 (SD 7.0) years (United
                      Kingdom) and 55.6 (SD 6.8) years (France). Sleep-related and
                      mental health problems were associated with earlier age of
                      AD diagnosis. The higher number of co-occurring conditions
                      the more likely the person with DS is diagnosed with AD at
                      an earlier age.Mean age of AD diagnosis in DS was relatively
                      consistent across countries. However, co-occurring
                      conditions varied and impacted on age of diagnosis,
                      suggesting that improvements can be made in diagnosing and
                      managing these conditions to delay onset of AD in DS.Mean
                      age of AD diagnosis was relatively consistent between
                      countries Sleep problems and mental health problems were
                      associated with earlier age of AD diagnosis APOE ε4
                      carriers were diagnosed with AD at an earlier age compared
                      to non-carriers Number of co-occurring conditions was
                      associated with earlier age of AD diagnosis No differences
                      between level of intellectual disability and mean age of AD
                      diagnosis.},
      keywords     = {Humans / Down Syndrome: epidemiology / Down Syndrome:
                      diagnosis / Down Syndrome: complications / Alzheimer
                      Disease: diagnosis / Alzheimer Disease: epidemiology / Male
                      / Female / Middle Aged / Europe: epidemiology / Adult /
                      United Kingdom: epidemiology / Sleep Wake Disorders:
                      epidemiology / Sleep Wake Disorders: diagnosis / Age Factors
                      / Age of Onset / France: epidemiology / Aged / Comorbidity /
                      Apolipoprotein E4: genetics / co‐occurring conditions
                      (Other) / Alzheimer's disease (Other) / Down syndrome
                      (Other) / age of diagnosis (Other) / co‐occurring
                      conditions (Other)},
      cin          = {AG Levin / Clinical Research (Munich)},
      ddc          = {610},
      cid          = {I:(DE-2719)1111016 / I:(DE-2719)1111015},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38506627},
      pmc          = {pmc:PMC11095427},
      doi          = {10.1002/alz.13779},
      url          = {https://pub.dzne.de/record/269680},
}