000269774 001__ 269774
000269774 005__ 20240630004218.0
000269774 0247_ $$2doi$$a10.3390/pathogens13050420
000269774 0247_ $$2pmid$$apmid:38787272
000269774 0247_ $$2pmc$$apmc:PMC11124347
000269774 0247_ $$2altmetric$$aaltmetric:163994098
000269774 037__ $$aDZNE-2024-00616
000269774 041__ $$aEnglish
000269774 082__ $$a610
000269774 1001_ $$aPaspaltsis, Ioannis$$b0
000269774 245__ $$aA Comparison of RML Prion Inactivation Efficiency by Heterogeneous and Homogeneous Photocatalysis.
000269774 260__ $$aBasel$$bMDPI$$c2024
000269774 3367_ $$2DRIVER$$aarticle
000269774 3367_ $$2DataCite$$aOutput Types/Journal article
000269774 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1716795997_24509
000269774 3367_ $$2BibTeX$$aARTICLE
000269774 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000269774 3367_ $$00$$2EndNote$$aJournal Article
000269774 520__ $$aPrions are proteinaceous pathogens responsible for a variety of devastating diseases in mammals, including scrapie in sheep and goats, chronic wasting disease in cervids, and Creutzfeldt-Jakob disease (CJD) in humans. They are characterized by their exceptional persistence to common inactivation procedures. This applies to all possible sources of prion contamination as prions may be present in the tissues and biological fluids of infected individuals. Hence, efficient prion inactivation procedures are still being sought to minimize the risk of intra- or inter-species transmission. In the past, photocatalytic treatment has been proven to be capable of efficiently oxidizing and inactivating prions. In the present study, the efficacy of homogeneous photo-Fenton-based photocatalysis as well as heterogeneous photocatalysis with TiO2 in reducing RML mouse scrapie infectivity was evaluated. Prion inactivation was assessed by means of a bioassay, and the results were confirmed by in vitro experiments. While the prion infectivity of the RML mouse scrapie was reduced after treatment with the photo-Fenton reagent, the heterogeneous photocatalytic treatment of the same prion strain completely eliminated prion infectivity.
000269774 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000269774 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000269774 650_7 $$2Other$$aRML prion
000269774 650_7 $$2Other$$aTiO2 photocatalysis
000269774 650_7 $$2Other$$aheterogeneous photocatalysis
000269774 650_7 $$2Other$$ahomogeneous photocatalysis
000269774 650_7 $$2Other$$aphoto-Fenton reagent
000269774 650_7 $$2Other$$aprion decontamination
000269774 650_7 $$2Other$$aprion inactivation
000269774 7001_ $$00000-0001-7363-9380$$aKanata, Eirini$$b1
000269774 7001_ $$aSotiriadis, Sotirios$$b2
000269774 7001_ $$0P:(DE-2719)9000766$$aCorreia, Susana Silva$$b3$$udzne
000269774 7001_ $$0P:(DE-2719)9000287$$aSchmitz, Matthias$$b4
000269774 7001_ $$0P:(DE-2719)2000058$$aZerr, Inga$$b5
000269774 7001_ $$00000-0003-4170-0612$$aDafou, Dimitra$$b6
000269774 7001_ $$00000-0001-8759-8962$$aXanthopoulos, Konstantinos$$b7
000269774 7001_ $$aSklaviadis, Theodoros$$b8
000269774 770__ $$aChronic Wasting Disease and Other Animal Prion Diseases: Towards the Comprehension of Animal Prion Pathologies
000269774 773__ $$0PERI:(DE-600)2695572-6$$a10.3390/pathogens13050420$$gVol. 13, no. 5, p. 420 -$$n5$$p420$$tPathogens$$v13$$x2076-0817$$y2024
000269774 8564_ $$uhttps://pub.dzne.de/record/269774/files/DZNE-2024-00616.pdf$$yOpenAccess
000269774 8564_ $$uhttps://pub.dzne.de/record/269774/files/DZNE-2024-00616.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000269774 909CO $$ooai:pub.dzne.de:269774$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000269774 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000766$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000269774 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000287$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000269774 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000058$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000269774 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000269774 9141_ $$y2024
000269774 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-26
000269774 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2023-04-12T15:01:22Z
000269774 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-26
000269774 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-10-26
000269774 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bPATHOGENS : 2022$$d2023-10-26
000269774 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-10-26
000269774 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2023-04-12T15:01:22Z
000269774 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2023-04-12T15:01:22Z
000269774 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-10-26
000269774 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2023-10-26
000269774 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-26
000269774 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-10-26
000269774 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000269774 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2023-04-12T15:01:22Z
000269774 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2023-10-26
000269774 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-26
000269774 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-10-26
000269774 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-26
000269774 9201_ $$0I:(DE-2719)1440011-1$$kAG Zerr$$lTranslational Studies and Biomarker$$x0
000269774 9201_ $$0I:(DE-2719)5000037$$kExt UMG Zerr$$lExt UMG Zerr$$x1
000269774 980__ $$ajournal
000269774 980__ $$aVDB
000269774 980__ $$aUNRESTRICTED
000269774 980__ $$aI:(DE-2719)1440011-1
000269774 980__ $$aI:(DE-2719)5000037
000269774 9801_ $$aFullTexts