Journal Article

DZNE-2024-00616

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A Comparison of RML Prion Inactivation Efficiency by Heterogeneous and Homogeneous Photocatalysis.

Paspaltsis, I. ; Kanata, E. ; Sotiriadis, S. ; Correia, S. S.DZNE* ; Schmitz, M.DZNE* ; Zerr, I.DZNE* ; Dafou, D. ; Xanthopoulos, K. ; Sklaviadis, T.

2024
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/pathogens13050420

Abstract: Prions are proteinaceous pathogens responsible for a variety of devastating diseases in mammals, including scrapie in sheep and goats, chronic wasting disease in cervids, and Creutzfeldt-Jakob disease (CJD) in humans. They are characterized by their exceptional persistence to common inactivation procedures. This applies to all possible sources of prion contamination as prions may be present in the tissues and biological fluids of infected individuals. Hence, efficient prion inactivation procedures are still being sought to minimize the risk of intra- or inter-species transmission. In the past, photocatalytic treatment has been proven to be capable of efficiently oxidizing and inactivating prions. In the present study, the efficacy of homogeneous photo-Fenton-based photocatalysis as well as heterogeneous photocatalysis with TiO2 in reducing RML mouse scrapie infectivity was evaluated. Prion inactivation was assessed by means of a bioassay, and the results were confirmed by in vitro experiments. While the prion infectivity of the RML mouse scrapie was reduced after treatment with the photo-Fenton reagent, the heterogeneous photocatalytic treatment of the same prion strain completely eliminated prion infectivity.

Keyword(s): RML prion ; TiO2 photocatalysis ; heterogeneous photocatalysis ; homogeneous photocatalysis ; photo-Fenton reagent ; prion decontamination ; prion inactivation

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Contributing Institute(s):

1. Translational Studies and Biomarker (AG Zerr)
2. Ext UMG Zerr (Ext UMG Zerr)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

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