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@ARTICLE{Paspaltsis:269774,
      author       = {Paspaltsis, Ioannis and Kanata, Eirini and Sotiriadis,
                      Sotirios and Correia, Susana Silva and Schmitz, Matthias and
                      Zerr, Inga and Dafou, Dimitra and Xanthopoulos, Konstantinos
                      and Sklaviadis, Theodoros},
      title        = {{A} {C}omparison of {RML} {P}rion {I}nactivation
                      {E}fficiency by {H}eterogeneous and {H}omogeneous
                      {P}hotocatalysis.},
      journal      = {Pathogens},
      volume       = {13},
      number       = {5},
      issn         = {2076-0817},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DZNE-2024-00616},
      pages        = {420},
      year         = {2024},
      abstract     = {Prions are proteinaceous pathogens responsible for a
                      variety of devastating diseases in mammals, including
                      scrapie in sheep and goats, chronic wasting disease in
                      cervids, and Creutzfeldt-Jakob disease (CJD) in humans. They
                      are characterized by their exceptional persistence to common
                      inactivation procedures. This applies to all possible
                      sources of prion contamination as prions may be present in
                      the tissues and biological fluids of infected individuals.
                      Hence, efficient prion inactivation procedures are still
                      being sought to minimize the risk of intra- or inter-species
                      transmission. In the past, photocatalytic treatment has been
                      proven to be capable of efficiently oxidizing and
                      inactivating prions. In the present study, the efficacy of
                      homogeneous photo-Fenton-based photocatalysis as well as
                      heterogeneous photocatalysis with TiO2 in reducing RML mouse
                      scrapie infectivity was evaluated. Prion inactivation was
                      assessed by means of a bioassay, and the results were
                      confirmed by in vitro experiments. While the prion
                      infectivity of the RML mouse scrapie was reduced after
                      treatment with the photo-Fenton reagent, the heterogeneous
                      photocatalytic treatment of the same prion strain completely
                      eliminated prion infectivity.},
      keywords     = {RML prion (Other) / TiO2 photocatalysis (Other) /
                      heterogeneous photocatalysis (Other) / homogeneous
                      photocatalysis (Other) / photo-Fenton reagent (Other) /
                      prion decontamination (Other) / prion inactivation (Other)},
      cin          = {AG Zerr / Ext UMG Zerr},
      ddc          = {610},
      cid          = {I:(DE-2719)1440011-1 / I:(DE-2719)5000037},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38787272},
      pmc          = {pmc:PMC11124347},
      doi          = {10.3390/pathogens13050420},
      url          = {https://pub.dzne.de/record/269774},
}