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| Home > Publications Database > A rule-based data-informed cellular consensus map of the human mononuclear phagocyte cell space |
| Home > Publications Database > A rule-based data-informed cellular consensus map of the human mononuclear phagocyte cell space |
| Preprint | DZNE-2024-00635 |
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2019
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Please use a persistent id in citations: doi:10.1101/658179
Abstract: Single-cell genomic techniques are opening new avenues to understand the basic units of life. Large international efforts, such as those to derive a Human Cell Atlas, are driving progress in this area; here, cellular map generation is key. To expedite the inevitable iterations of these underlying maps, we have developed a rule-based data-informed approach to build next generation cellular consensus maps. Using the human dendritic-cell and monocyte compartment in peripheral blood as an example, we performed computational integration of previous, partially overlapping maps using an approach we termed ‘backmapping’, combined with multi-color flow-cytometry and index sorting-based single-cell RNA-sequencing. Our general strategy can be applied to any atlas generation for humans and other species.
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