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@ARTICLE{Melas:269834,
      author       = {Melas, Konstantinos and Talevi, Valentina and Etteldorf,
                      Rika and Estrada, Santiago and Krüger, Dennis Manfred and
                      Pena, Tonatiuh and Aziz, N. Ahmad and Fischer, André and
                      Breteler, Monique},
      title        = {{C}irculating micro{RNA}s are related to cognitive domains
                      in the general population},
      reportid     = {DZNE-2024-00669},
      year         = {2024},
      abstract     = {INTRODUCTION: Circulating microRNAs have been suggested as
                      candidates for detecting and preventing subclinical
                      cognitive dysfunction. However, replication of previous
                      findings and identification of novel microRNAs associated
                      with cognitive domains, including their relation to brain
                      structure and the pathways they regulate, are still
                      lacking.METHODS: We examined circulating microRNAs and
                      microRNA co-expression clusters in relation to cognitive
                      domains, structural MRI measures, and target gene expression
                      in 2869 participants of a population-based cohort.RESULTS:
                      Five previously identified and 10 novel microRNAs were
                      associated with cognitive domains. Importantly, seven of
                      these microRNAs were also associated with cortical thickness
                      and two with hippocampal volume. Functional genomics
                      analysis showed that the identified microRNAs regulated
                      genes in pathways like neurogenesis, axon guidance, and
                      synapse assembly.DISCUSSION: We identified microRNAs
                      associated with cognitive domains, brain regions, and
                      neuronal processes affected by aging and neurodegeneration,
                      making them promising candidate blood-based biomarkers or
                      therapeutic targets of subclinical cognitive dysfunction.},
      cin          = {AG Breteler / AG Aziz / AG Fischer},
      cid          = {I:(DE-2719)1012001 / I:(DE-2719)5000071 /
                      I:(DE-2719)1410002},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354) / 352
                      - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-354 / G:(DE-HGF)POF4-352},
      experiment   = {EXP:(DE-2719)Rhineland Study-20190321},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2024.05.07.24306994},
      url          = {https://pub.dzne.de/record/269834},
}