TY  - JOUR
AU  - Ku, Shih-Pi
AU  - Atucha, Erika
AU  - Alavi, Nico
AU  - Mulla-Osman, Halla
AU  - Kayumova, Rukhshona
AU  - Yoshida, Motoharu
AU  - Csicsvari, Jozsef
AU  - Sauvage, Magdalena M.
TI  - Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance
JO  - Cell reports
VL  - 43
IS  - 6
SN  - 2211-1247
CY  - [New York, NY]
PB  - Elsevier
M1  - DZNE-2024-00688
SP  - 114276
PY  - 2024
AB  - How the coordination of neuronal spiking and brain rhythms between hippocampal subregions supports memory function remains elusive. We studied the interregional coordination of CA3 neuronal spiking with CA1 theta oscillations by recording electrophysiological signals along the proximodistal axis of the hippocampus in rats that were performing a high-memory-demand recognition memory task adapted from humans. We found that CA3 population spiking occurs preferentially at the peak of distal CA1 theta oscillations when memory was tested but only when previously encountered stimuli were presented. In addition, decoding analyses revealed that only population cell firing of proximal CA3 together with that of distal CA1 can predict performance at test in the present non-spatial task. Overall, our work demonstrates an important role for the synchronization of CA3 neuronal activity with CA1 theta oscillations during memory testing.
KW  - Animals
KW  - Theta Rhythm: physiology
KW  - CA1 Region, Hippocampal: physiology
KW  - Male
KW  - Rats
KW  - CA3 Region, Hippocampal: physiology
KW  - Memory: physiology
KW  - Neurons: physiology
KW  - Action Potentials: physiology
KW  - CA1 (Other)
KW  - CA3 (Other)
KW  - CP: Neuroscience (Other)
KW  - distal (Other)
KW  - hippocampus (Other)
KW  - odor (Other)
KW  - population coding (Other)
KW  - proximal (Other)
KW  - recognition memory (Other)
KW  - support vector machine (Other)
KW  - theta (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38814781
DO  - DOI:10.1016/j.celrep.2024.114276
UR  - https://pub.dzne.de/record/269862
ER  -