Journal Article

DZNE-2024-00688

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance

Ku, S.-P. ; Atucha, E. ; Alavi, N. ; Mulla-Osman, H. ; Kayumova, R. ; Yoshida, M.DZNE* ; Csicsvari, J. ; Sauvage, M. M.

2024
Elsevier [New York, NY]

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Please use a persistent id in citations: doi:10.1016/j.celrep.2024.114276

Abstract: How the coordination of neuronal spiking and brain rhythms between hippocampal subregions supports memory function remains elusive. We studied the interregional coordination of CA3 neuronal spiking with CA1 theta oscillations by recording electrophysiological signals along the proximodistal axis of the hippocampus in rats that were performing a high-memory-demand recognition memory task adapted from humans. We found that CA3 population spiking occurs preferentially at the peak of distal CA1 theta oscillations when memory was tested but only when previously encountered stimuli were presented. In addition, decoding analyses revealed that only population cell firing of proximal CA3 together with that of distal CA1 can predict performance at test in the present non-spatial task. Overall, our work demonstrates an important role for the synchronization of CA3 neuronal activity with CA1 theta oscillations during memory testing.

Keyword(s): Animals (MeSH) ; Theta Rhythm: physiology (MeSH) ; CA1 Region, Hippocampal: physiology (MeSH) ; Male (MeSH) ; Rats (MeSH) ; CA3 Region, Hippocampal: physiology (MeSH) ; Memory: physiology (MeSH) ; Neurons: physiology (MeSH) ; Action Potentials: physiology (MeSH) ; CA1 ; CA3 ; CP: Neuroscience ; distal ; hippocampus ; odor ; population coding ; proximal ; recognition memory ; support vector machine ; theta

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Contributing Institute(s):

1. Cognitive Neurophysiology (AG Yoshida)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2024

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