Journal Article

DZNE-2024-00765

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png RTMS of the Cerebellum Using an Accelerated Stimulation Protocol Improved Gait in Parkinson's Disease.

Grobe-Einsler, M. (First author)DZNE* ; Lupa, A. ; Weller, J. ; Kaut, O.

2024
Sage Thousand Oaks, Calif.

This record in other databases:    

Please use a persistent id in citations: doi:10.1177/15459683241257518

Abstract: Repetitive transcranial magnetic stimulation (rTMS) is a nonpharmacological and noninvasive brain stimulation technique that has been proven to be effective in Parkinson's disease (PD). The combination of rTMS and treadmill training improved gait function in PD greater than treadmill training alone.The aim of our study was to evaluate the combination of a novel high-intensity, short intervention rTMS treatment and a multimodal treatment protocol including of physiotherapy, occupational therapy and language therapy, the so-called Parkinson's Disease Multimodal Complex Treatment (PD-MCT), to improve motor function.In this randomized double-blind sham-controlled trial rTMS with 48 Hz or sham was applied over the cerebellum 3 times a day for 5 consecutive days. Patients were assessed at baseline (V0), after 5 days of treatment (V1), and 4 weeks later (V2). The primary clinical outcome measure was the motor sum-score of the Unified PD Rating Scale (UPDRSIII), secondary clinical outcomes were quantitative motor tasks.A total of 36 PD patients were randomly allocated either to rTMS (n = 20) or sham (n = 16), both combined with PD-MCT. rTMS improved the UDPRSIII score comparing baseline and V1 in the treatment group by -8.2 points (P = .004). The 8MW and dynamic posturography remained unchanged in both groups after intervention. Conclusion. Compressing weeks of canonical rTMS protocols into 5 days was effective and well tolerated. rTMS may serve as an add-on therapy for augmenting the multimodal complex treatment of motor symptoms, but seems to be ineffective to treat postural instability.

Keyword(s): Humans (MeSH) ; Parkinson Disease: therapy (MeSH) ; Parkinson Disease: physiopathology (MeSH) ; Parkinson Disease: complications (MeSH) ; Parkinson Disease: rehabilitation (MeSH) ; Male (MeSH) ; Female (MeSH) ; Transcranial Magnetic Stimulation (MeSH) ; Aged (MeSH) ; Double-Blind Method (MeSH) ; Middle Aged (MeSH) ; Cerebellum: physiopathology (MeSH) ; Combined Modality Therapy (MeSH) ; Gait Disorders, Neurologic: etiology (MeSH) ; Gait Disorders, Neurologic: rehabilitation (MeSH) ; Gait Disorders, Neurologic: therapy (MeSH) ; Gait Disorders, Neurologic: physiopathology (MeSH) ; Outcome Assessment, Health Care (MeSH) ; Treatment Outcome (MeSH) ; Parkinson’s disease ; Parkinson ; Parkinson’s disease ; TMS ; cerebellum ; multimodal complex treatment ; rTMS

---

Contributing Institute(s):

1. Patient Studies (AG Klockgether)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

---

Database coverage:
; Clarivate Analytics Master Journal List ; Essential Science Indicators ; IF < 5 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---