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000270707 1001_ $$0P:(DE-2719)9001018$$aMethi, Aditi$$b0$$eFirst author$$udzne
000270707 245__ $$aA Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise.
000270707 260__ $$aTotowa, NJ$$bHumana Press$$c2024
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000270707 520__ $$aExercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a vital brain region responsible for learning and memory. Previous research has demonstrated that exercise-mediated improvement of learning and memory in humans and rodents correlates with increased adult neurogenesis and processes related to enhanced synaptic plasticity. Nevertheless, the underlying molecular mechanisms are not fully understood. With the aim to further elucidate these mechanisms, we provide a comprehensive dataset of the mouse hippocampal transcriptome at the single-cell level after 4 weeks of voluntary wheel-running. Our analysis provides a number of interesting observations. For example, the results suggest that exercise affects adult neurogenesis by accelerating the maturation of a subpopulation of Prdm16-expressing neurons. Moreover, we uncover the existence of an intricate crosstalk among multiple vital signaling pathways such as NF-κB, Wnt/β-catenin, Notch, and retinoic acid (RA) pathways altered upon exercise in a specific cluster of excitatory neurons within the Cornu Ammonis (CA) region of the hippocampus. In conclusion, our study provides an important resource dataset and sheds further light on the molecular changes induced by exercise in the hippocampus. These findings have implications for developing targeted interventions aimed at optimizing cognitive health and preventing age-related cognitive decline.
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000270707 650_7 $$2Other$$aAerobic exercise
000270707 650_7 $$2Other$$aCognitive decline
000270707 650_7 $$2Other$$aDementia
000270707 650_7 $$2Other$$aEnvironmental enrichment
000270707 650_7 $$2Other$$aGene-expression
000270707 650_7 $$2Other$$aHippocampus
000270707 650_7 $$2Other$$aLearning and memory
000270707 650_7 $$2Other$$aSingle-cell RNAseq
000270707 650_2 $$2MeSH$$aAnimals
000270707 650_2 $$2MeSH$$aHippocampus: metabolism
000270707 650_2 $$2MeSH$$aPhysical Conditioning, Animal: physiology
000270707 650_2 $$2MeSH$$aSingle-Cell Analysis
000270707 650_2 $$2MeSH$$aGene Expression Profiling
000270707 650_2 $$2MeSH$$aTranscriptome: genetics
000270707 650_2 $$2MeSH$$aMice, Inbred C57BL
000270707 650_2 $$2MeSH$$aMice
000270707 650_2 $$2MeSH$$aMale
000270707 650_2 $$2MeSH$$aNeurogenesis
000270707 650_2 $$2MeSH$$aNeurons: metabolism
000270707 650_2 $$2MeSH$$aSignal Transduction
000270707 650_2 $$2MeSH$$aVolition
000270707 7001_ $$0P:(DE-2719)2811643$$aIslam, Rezaul$$b1$$eFirst author$$udzne
000270707 7001_ $$0P:(DE-2719)2812832$$aKaurani, Lalit$$b2$$udzne
000270707 7001_ $$0P:(DE-2719)2812054$$aSakib, M Sadman$$b3$$udzne
000270707 7001_ $$0P:(DE-2719)2812548$$aKrüger, Dennis M$$b4$$udzne
000270707 7001_ $$0P:(DE-2719)2811063$$aPena, Tonatiuh$$b5$$udzne
000270707 7001_ $$0P:(DE-2719)2810773$$aBurkhardt, Susanne$$b6$$udzne
000270707 7001_ $$0P:(DE-HGF)0$$aLiebetanz, David$$b7
000270707 7001_ $$0P:(DE-2719)2000047$$aFischer, André$$b8$$eLast author
000270707 773__ $$0PERI:(DE-600)2079384-4$$a10.1007/s12035-023-03869-9$$gVol. 61, no. 8, p. 5628 - 5645$$n8$$p5628 - 5645$$tMolecular neurobiology$$v61$$x0893-7648$$y2024
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