Journal Article

DZNE-2024-00879

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise.

Methi, A. (First author)DZNE* ; Islam, R. (First author)DZNE* ; Kaurani, L.DZNE* ; Sakib, M. S.DZNE* ; Krüger, D. M.DZNE* ; Pena, T.DZNE* ; Burkhardt, S.DZNE* ; Liebetanz, D. ; Fischer, A. (Last author)DZNE*

2024
Humana Press Totowa, NJ

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Please use a persistent id in citations: doi:10.1007/s12035-023-03869-9

Abstract: Exercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a vital brain region responsible for learning and memory. Previous research has demonstrated that exercise-mediated improvement of learning and memory in humans and rodents correlates with increased adult neurogenesis and processes related to enhanced synaptic plasticity. Nevertheless, the underlying molecular mechanisms are not fully understood. With the aim to further elucidate these mechanisms, we provide a comprehensive dataset of the mouse hippocampal transcriptome at the single-cell level after 4 weeks of voluntary wheel-running. Our analysis provides a number of interesting observations. For example, the results suggest that exercise affects adult neurogenesis by accelerating the maturation of a subpopulation of Prdm16-expressing neurons. Moreover, we uncover the existence of an intricate crosstalk among multiple vital signaling pathways such as NF-κB, Wnt/β-catenin, Notch, and retinoic acid (RA) pathways altered upon exercise in a specific cluster of excitatory neurons within the Cornu Ammonis (CA) region of the hippocampus. In conclusion, our study provides an important resource dataset and sheds further light on the molecular changes induced by exercise in the hippocampus. These findings have implications for developing targeted interventions aimed at optimizing cognitive health and preventing age-related cognitive decline.

Keyword(s): Animals (MeSH) ; Hippocampus: metabolism (MeSH) ; Physical Conditioning, Animal: physiology (MeSH) ; Single-Cell Analysis (MeSH) ; Gene Expression Profiling (MeSH) ; Transcriptome: genetics (MeSH) ; Mice, Inbred C57BL (MeSH) ; Mice (MeSH) ; Male (MeSH) ; Neurogenesis (MeSH) ; Neurons: metabolism (MeSH) ; Signal Transduction (MeSH) ; Volition (MeSH) ; Aerobic exercise ; Cognitive decline ; Dementia ; Environmental enrichment ; Gene-expression ; Hippocampus ; Learning and memory ; Single-cell RNAseq

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Contributing Institute(s):

1. Epigenetics and Systems Medicine in Neurodegenerative Diseases (AG Fischer)
2. Bioinformatics and Genome Dynamics Core (Bioinformatics and Genome Dynamics Core ; Bioinformatics Unit)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2024

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DEAL Springer ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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