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@ARTICLE{Methi:270707,
      author       = {Methi, Aditi and Islam, Rezaul and Kaurani, Lalit and
                      Sakib, M Sadman and Krüger, Dennis M and Pena, Tonatiuh and
                      Burkhardt, Susanne and Liebetanz, David and Fischer, André},
      title        = {{A} {S}ingle-{C}ell {T}ranscriptomic {A}nalysis of the
                      {M}ouse {H}ippocampus {A}fter {V}oluntary {E}xercise.},
      journal      = {Molecular neurobiology},
      volume       = {61},
      number       = {8},
      issn         = {0893-7648},
      address      = {Totowa, NJ},
      publisher    = {Humana Press},
      reportid     = {DZNE-2024-00879},
      pages        = {5628 - 5645},
      year         = {2024},
      abstract     = {Exercise has been recognized as a beneficial factor for
                      cognitive health, particularly in relation to the
                      hippocampus, a vital brain region responsible for learning
                      and memory. Previous research has demonstrated that
                      exercise-mediated improvement of learning and memory in
                      humans and rodents correlates with increased adult
                      neurogenesis and processes related to enhanced synaptic
                      plasticity. Nevertheless, the underlying molecular
                      mechanisms are not fully understood. With the aim to further
                      elucidate these mechanisms, we provide a comprehensive
                      dataset of the mouse hippocampal transcriptome at the
                      single-cell level after 4 weeks of voluntary wheel-running.
                      Our analysis provides a number of interesting observations.
                      For example, the results suggest that exercise affects adult
                      neurogenesis by accelerating the maturation of a
                      subpopulation of Prdm16-expressing neurons. Moreover, we
                      uncover the existence of an intricate crosstalk among
                      multiple vital signaling pathways such as NF-κB,
                      Wnt/β-catenin, Notch, and retinoic acid (RA) pathways
                      altered upon exercise in a specific cluster of excitatory
                      neurons within the Cornu Ammonis (CA) region of the
                      hippocampus. In conclusion, our study provides an important
                      resource dataset and sheds further light on the molecular
                      changes induced by exercise in the hippocampus. These
                      findings have implications for developing targeted
                      interventions aimed at optimizing cognitive health and
                      preventing age-related cognitive decline.},
      keywords     = {Animals / Hippocampus: metabolism / Physical Conditioning,
                      Animal: physiology / Single-Cell Analysis / Gene Expression
                      Profiling / Transcriptome: genetics / Mice, Inbred C57BL /
                      Mice / Male / Neurogenesis / Neurons: metabolism / Signal
                      Transduction / Volition / Aerobic exercise (Other) /
                      Cognitive decline (Other) / Dementia (Other) / Environmental
                      enrichment (Other) / Gene-expression (Other) / Hippocampus
                      (Other) / Learning and memory (Other) / Single-cell RNAseq
                      (Other)},
      cin          = {AG Fischer / Bioinformatics and Genome Dynamics Core ;
                      Bioinformatics Unit},
      ddc          = {570},
      cid          = {I:(DE-2719)1410002 / I:(DE-2719)1440016},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11249425},
      pubmed       = {pmid:38217668},
      doi          = {10.1007/s12035-023-03869-9},
      url          = {https://pub.dzne.de/record/270707},
}