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001     270707
005     20240808164643.0
024 7 _ |a pmc:PMC11249425
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024 7 _ |a 10.1007/s12035-023-03869-9
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024 7 _ |a pmid:38217668
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024 7 _ |a 0893-7648
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024 7 _ |a 1559-1182
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037 _ _ |a DZNE-2024-00879
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Methi, Aditi
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245 _ _ |a A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise.
260 _ _ |a Totowa, NJ
|c 2024
|b Humana Press
336 7 _ |a article
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336 7 _ |a ARTICLE
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520 _ _ |a Exercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a vital brain region responsible for learning and memory. Previous research has demonstrated that exercise-mediated improvement of learning and memory in humans and rodents correlates with increased adult neurogenesis and processes related to enhanced synaptic plasticity. Nevertheless, the underlying molecular mechanisms are not fully understood. With the aim to further elucidate these mechanisms, we provide a comprehensive dataset of the mouse hippocampal transcriptome at the single-cell level after 4 weeks of voluntary wheel-running. Our analysis provides a number of interesting observations. For example, the results suggest that exercise affects adult neurogenesis by accelerating the maturation of a subpopulation of Prdm16-expressing neurons. Moreover, we uncover the existence of an intricate crosstalk among multiple vital signaling pathways such as NF-κB, Wnt/β-catenin, Notch, and retinoic acid (RA) pathways altered upon exercise in a specific cluster of excitatory neurons within the Cornu Ammonis (CA) region of the hippocampus. In conclusion, our study provides an important resource dataset and sheds further light on the molecular changes induced by exercise in the hippocampus. These findings have implications for developing targeted interventions aimed at optimizing cognitive health and preventing age-related cognitive decline.
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650 _ 7 |a Aerobic exercise
|2 Other
650 _ 7 |a Cognitive decline
|2 Other
650 _ 7 |a Dementia
|2 Other
650 _ 7 |a Environmental enrichment
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650 _ 7 |a Gene-expression
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650 _ 7 |a Hippocampus
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650 _ 7 |a Learning and memory
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650 _ 7 |a Single-cell RNAseq
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650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Hippocampus: metabolism
|2 MeSH
650 _ 2 |a Physical Conditioning, Animal: physiology
|2 MeSH
650 _ 2 |a Single-Cell Analysis
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650 _ 2 |a Gene Expression Profiling
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650 _ 2 |a Transcriptome: genetics
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
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650 _ 2 |a Mice
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650 _ 2 |a Male
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650 _ 2 |a Neurogenesis
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650 _ 2 |a Neurons: metabolism
|2 MeSH
650 _ 2 |a Signal Transduction
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650 _ 2 |a Volition
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700 1 _ |a Islam, Rezaul
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700 1 _ |a Kaurani, Lalit
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700 1 _ |a Sakib, M Sadman
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700 1 _ |a Krüger, Dennis M
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700 1 _ |a Pena, Tonatiuh
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700 1 _ |a Burkhardt, Susanne
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700 1 _ |a Liebetanz, David
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700 1 _ |a Fischer, André
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773 _ _ |a 10.1007/s12035-023-03869-9
|g Vol. 61, no. 8, p. 5628 - 5645
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|t Molecular neurobiology
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|y 2024
|x 0893-7648
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