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000271134 1001_ $$0P:(DE-2719)9001803$$aKedia, Shreeya$$b0$$eFirst author$$udzne
000271134 245__ $$aT cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.
000271134 260__ $$aNew York, NY$$bNature America$$c2024
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000271134 520__ $$aAge-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer's disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer's disease, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, our data suggest that immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.
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000271134 650_2 $$2MeSH$$aAnimals
000271134 650_2 $$2MeSH$$aMicroglia: pathology
000271134 650_2 $$2MeSH$$aMicroglia: metabolism
000271134 650_2 $$2MeSH$$aMicroglia: immunology
000271134 650_2 $$2MeSH$$aMyelin Sheath: pathology
000271134 650_2 $$2MeSH$$aMyelin Sheath: metabolism
000271134 650_2 $$2MeSH$$aMice
000271134 650_2 $$2MeSH$$aDisease Models, Animal
000271134 650_2 $$2MeSH$$aAmyloidosis: pathology
000271134 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000271134 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000271134 650_2 $$2MeSH$$aAlzheimer Disease: immunology
000271134 650_2 $$2MeSH$$aCD8-Positive T-Lymphocytes: immunology
000271134 650_2 $$2MeSH$$aMice, Transgenic
000271134 650_2 $$2MeSH$$aOligodendroglia: pathology
000271134 650_2 $$2MeSH$$aOligodendroglia: metabolism
000271134 650_2 $$2MeSH$$aMice, Inbred C57BL
000271134 7001_ $$aJi, Hao$$b1
000271134 7001_ $$0P:(DE-2719)9002625$$aFeng, Ruoqing$$b2$$udzne
000271134 7001_ $$0P:(DE-2719)9002905$$aAndrovic, Peter$$b3$$udzne
000271134 7001_ $$0P:(DE-2719)9002306$$aSpieth, Lena$$b4$$udzne
000271134 7001_ $$0P:(DE-2719)9002890$$aLiu, Lu$$b5$$udzne
000271134 7001_ $$00000-0001-7523-6622$$aFranz, Jonas$$b6
000271134 7001_ $$00009-0009-1341-3107$$aZdiarstek, Hanna$$b7
000271134 7001_ $$aAnderson, Katrin Perez$$b8
000271134 7001_ $$0P:(DE-2719)9001806$$aKaboglu, Cem Busra$$b9$$udzne
000271134 7001_ $$0P:(DE-2719)9002904$$aLiu, Qian$$b10$$udzne
000271134 7001_ $$0P:(DE-2719)9000661$$aMattugini, Nicola$$b11$$udzne
000271134 7001_ $$0P:(DE-HGF)0$$aCherif, Fatma$$b12
000271134 7001_ $$0P:(DE-2719)9002550$$aPrtvar, Danilo$$b13$$udzne
000271134 7001_ $$0P:(DE-2719)2812590$$aCantuti-Castelvetri, Ludovico$$b14
000271134 7001_ $$00000-0002-9069-2594$$aLiesz, Arthur$$b15
000271134 7001_ $$0P:(DE-2719)2812260$$aSchifferer, Martina$$b16
000271134 7001_ $$0P:(DE-2719)9000922$$aStadelmann, Christine$$b17
000271134 7001_ $$0P:(DE-2719)2442036$$aTahirovic, Sabina$$b18
000271134 7001_ $$0P:(DE-2719)9002754$$aGokce, Ozgun$$b19
000271134 7001_ $$0P:(DE-2719)2811642$$aSimons, Mikael$$b20$$eLast author
000271134 773__ $$0PERI:(DE-600)1494955-6$$a10.1038/s41593-024-01682-8$$gVol. 27, no. 8, p. 1468 - 1474$$n8$$p1468 - 1474$$tNature neuroscience$$v27$$x1097-6256$$y2024
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