Journal Article

DZNE-2024-01002

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.

Kedia, S. (First author)DZNE* ; Ji, H. ; Feng, R.DZNE* ; Androvic, P.Extern* ; Spieth, L.DZNE* ; Liu, L.Extern* ; Franz, J. ; Zdiarstek, H. ; Anderson, K. P. ; Kaboglu, C. B.Extern* ; Liu, Q.Extern* ; Mattugini, N.DZNE* ; Cherif, F.DZNE* ; Prtvar, D.DZNE* ; Cantuti-Castelvetri, L.DZNE* ; Liesz, A. ; Schifferer, M.DZNE* ; Stadelmann, C. ; Tahirovic, S.DZNE* ; Gokce, O.DZNE* ; Simons, M. (Last author)DZNE*

2024
Nature America New York, NY

This record in other databases:    

Please use a persistent id in citations: doi:10.1038/s41593-024-01682-8

Abstract: Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer's disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer's disease, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, our data suggest that immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.

Keyword(s): Animals (MeSH) ; Microglia: pathology (MeSH) ; Microglia: metabolism (MeSH) ; Microglia: immunology (MeSH) ; Myelin Sheath: pathology (MeSH) ; Myelin Sheath: metabolism (MeSH) ; Mice (MeSH) ; Disease Models, Animal (MeSH) ; Amyloidosis: pathology (MeSH) ; Alzheimer Disease: pathology (MeSH) ; Alzheimer Disease: metabolism (MeSH) ; Alzheimer Disease: immunology (MeSH) ; CD8-Positive T-Lymphocytes: immunology (MeSH) ; Mice, Transgenic (MeSH) ; Oligodendroglia: pathology (MeSH) ; Oligodendroglia: metabolism (MeSH) ; Mice, Inbred C57BL (MeSH)

---

Contributing Institute(s):

1. Molecular Neurobiology (AG Simons)
2. Juvenile Neurodegeneration (AG Tahirovic)
3. Neuronal Cell Biology (AG Misgeld)
4. Spatial Dynamics of Neurodegeneration (AG Gokce)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)
2. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2024

---

Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Nature ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 20 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---