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001     271134
005     20240818004549.0
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024 7 _ |a 10.1038/s41593-024-01682-8
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024 7 _ |a pmid:38937583
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024 7 _ |a 1097-6256
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024 7 _ |a 1546-1726
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100 1 _ |a Kedia, Shreeya
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245 _ _ |a T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.
260 _ _ |a New York, NY
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|b Nature America
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520 _ _ |a Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer's disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer's disease, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, our data suggest that immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.
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650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Microglia: pathology
|2 MeSH
650 _ 2 |a Microglia: metabolism
|2 MeSH
650 _ 2 |a Microglia: immunology
|2 MeSH
650 _ 2 |a Myelin Sheath: pathology
|2 MeSH
650 _ 2 |a Myelin Sheath: metabolism
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Disease Models, Animal
|2 MeSH
650 _ 2 |a Amyloidosis: pathology
|2 MeSH
650 _ 2 |a Alzheimer Disease: pathology
|2 MeSH
650 _ 2 |a Alzheimer Disease: metabolism
|2 MeSH
650 _ 2 |a Alzheimer Disease: immunology
|2 MeSH
650 _ 2 |a CD8-Positive T-Lymphocytes: immunology
|2 MeSH
650 _ 2 |a Mice, Transgenic
|2 MeSH
650 _ 2 |a Oligodendroglia: pathology
|2 MeSH
650 _ 2 |a Oligodendroglia: metabolism
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
700 1 _ |a Ji, Hao
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700 1 _ |a Feng, Ruoqing
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700 1 _ |a Androvic, Peter
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700 1 _ |a Spieth, Lena
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700 1 _ |a Liu, Lu
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700 1 _ |a Franz, Jonas
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700 1 _ |a Zdiarstek, Hanna
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700 1 _ |a Anderson, Katrin Perez
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700 1 _ |a Kaboglu, Cem Busra
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700 1 _ |a Liu, Qian
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700 1 _ |a Mattugini, Nicola
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700 1 _ |a Cherif, Fatma
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700 1 _ |a Prtvar, Danilo
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700 1 _ |a Cantuti-Castelvetri, Ludovico
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700 1 _ |a Liesz, Arthur
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700 1 _ |a Schifferer, Martina
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700 1 _ |a Stadelmann, Christine
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700 1 _ |a Tahirovic, Sabina
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700 1 _ |a Gokce, Ozgun
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700 1 _ |a Simons, Mikael
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773 _ _ |a 10.1038/s41593-024-01682-8
|g Vol. 27, no. 8, p. 1468 - 1474
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|p 1468 - 1474
|t Nature neuroscience
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