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000271346 041__ $$aEnglish
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000271346 1001_ $$0P:(DE-2719)2810548$$aZocher, Sara$$b0$$eLast author
000271346 245__ $$aTargeting neuronal epigenomes for brain rejuvenation.
000271346 260__ $$aHoboken, NJ [u.a.]$$bWiley$$c2024
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000271346 520__ $$aAging is associated with a progressive decline of brain function, and the underlying causes and possible interventions to prevent this cognitive decline have been the focus of intense investigation. The maintenance of neuronal function over the lifespan requires proper epigenetic regulation, and accumulating evidence suggests that the deterioration of the neuronal epigenetic landscape contributes to brain dysfunction during aging. Epigenetic aging of neurons may, however, be malleable. Recent reports have shown age-related epigenetic changes in neurons to be reversible and targetable by rejuvenation strategies that can restore brain function during aging. This review discusses the current evidence that identifies neuronal epigenetic aging as a driver of cognitive decline and a promising target of brain rejuvenation strategies, and it highlights potential approaches for the specific manipulation of the aging neuronal epigenome to restore a youthful epigenetic state in the brain.
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000271346 650_7 $$2Other$$aCognitive Decline
000271346 650_7 $$2Other$$aEpigenetic Rejuvenation
000271346 650_7 $$2Other$$aEpigenome Editing
000271346 650_7 $$2Other$$aNeuron Aging
000271346 650_7 $$2Other$$aNeuronal Epigenome
000271346 650_2 $$2MeSH$$aHumans
000271346 650_2 $$2MeSH$$aBrain: metabolism
000271346 650_2 $$2MeSH$$aEpigenesis, Genetic
000271346 650_2 $$2MeSH$$aAnimals
000271346 650_2 $$2MeSH$$aNeurons: metabolism
000271346 650_2 $$2MeSH$$aAging: genetics
000271346 650_2 $$2MeSH$$aEpigenome
000271346 650_2 $$2MeSH$$aRejuvenation: physiology
000271346 650_2 $$2MeSH$$aCognitive Dysfunction: genetics
000271346 650_2 $$2MeSH$$aCognitive Dysfunction: metabolism
000271346 773__ $$0PERI:(DE-600)1467419-1$$a10.1038/s44318-024-00148-8$$gVol. 43, no. 16, p. 3312 - 3326$$n16$$p3312 - 3326$$tThe EMBO journal$$v43$$x0261-4189$$y2024
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