Journal Article (Review Article)

DZNE-2024-01047

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Targeting neuronal epigenomes for brain rejuvenation.

Zocher, S. (Last author)DZNE*

2024
Wiley Hoboken, NJ [u.a.]

This record in other databases:    

Please use a persistent id in citations: doi:10.1038/s44318-024-00148-8

Abstract: Aging is associated with a progressive decline of brain function, and the underlying causes and possible interventions to prevent this cognitive decline have been the focus of intense investigation. The maintenance of neuronal function over the lifespan requires proper epigenetic regulation, and accumulating evidence suggests that the deterioration of the neuronal epigenetic landscape contributes to brain dysfunction during aging. Epigenetic aging of neurons may, however, be malleable. Recent reports have shown age-related epigenetic changes in neurons to be reversible and targetable by rejuvenation strategies that can restore brain function during aging. This review discusses the current evidence that identifies neuronal epigenetic aging as a driver of cognitive decline and a promising target of brain rejuvenation strategies, and it highlights potential approaches for the specific manipulation of the aging neuronal epigenome to restore a youthful epigenetic state in the brain.

Keyword(s): Humans (MeSH) ; Brain: metabolism (MeSH) ; Epigenesis, Genetic (MeSH) ; Animals (MeSH) ; Neurons: metabolism (MeSH) ; Aging: genetics (MeSH) ; Epigenome (MeSH) ; Rejuvenation: physiology (MeSH) ; Cognitive Dysfunction: genetics (MeSH) ; Cognitive Dysfunction: metabolism (MeSH) ; Cognitive Decline ; Epigenetic Rejuvenation ; Epigenome Editing ; Neuron Aging ; Neuronal Epigenome

---

Contributing Institute(s):

1. Nuclear Architecture in Neural Plasticity and Aging (AG Toda ; AG Toda)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2024

---

Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---