TY  - JOUR
AU  - Zocher, Sara
TI  - Targeting neuronal epigenomes for brain rejuvenation.
JO  - The EMBO journal
VL  - 43
IS  - 16
SN  - 0261-4189
CY  - Hoboken, NJ [u.a.]
PB  - Wiley
M1  - DZNE-2024-01047
SP  - 3312 - 3326
PY  - 2024
AB  - Aging is associated with a progressive decline of brain function, and the underlying causes and possible interventions to prevent this cognitive decline have been the focus of intense investigation. The maintenance of neuronal function over the lifespan requires proper epigenetic regulation, and accumulating evidence suggests that the deterioration of the neuronal epigenetic landscape contributes to brain dysfunction during aging. Epigenetic aging of neurons may, however, be malleable. Recent reports have shown age-related epigenetic changes in neurons to be reversible and targetable by rejuvenation strategies that can restore brain function during aging. This review discusses the current evidence that identifies neuronal epigenetic aging as a driver of cognitive decline and a promising target of brain rejuvenation strategies, and it highlights potential approaches for the specific manipulation of the aging neuronal epigenome to restore a youthful epigenetic state in the brain.
KW  - Humans
KW  - Brain: metabolism
KW  - Epigenesis, Genetic
KW  - Animals
KW  - Neurons: metabolism
KW  - Aging: genetics
KW  - Epigenome
KW  - Rejuvenation: physiology
KW  - Cognitive Dysfunction: genetics
KW  - Cognitive Dysfunction: metabolism
KW  - Cognitive Decline (Other)
KW  - Epigenetic Rejuvenation (Other)
KW  - Epigenome Editing (Other)
KW  - Neuron Aging (Other)
KW  - Neuronal Epigenome (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39009672
C2  - pmc:PMC11329789
DO  - DOI:10.1038/s44318-024-00148-8
UR  - https://pub.dzne.de/record/271346
ER  -