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@ARTICLE{Zocher:271346,
      author       = {Zocher, Sara},
      title        = {{T}argeting neuronal epigenomes for brain rejuvenation.},
      journal      = {The EMBO journal},
      volume       = {43},
      number       = {16},
      issn         = {0261-4189},
      address      = {Hoboken, NJ [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2024-01047},
      pages        = {3312 - 3326},
      year         = {2024},
      abstract     = {Aging is associated with a progressive decline of brain
                      function, and the underlying causes and possible
                      interventions to prevent this cognitive decline have been
                      the focus of intense investigation. The maintenance of
                      neuronal function over the lifespan requires proper
                      epigenetic regulation, and accumulating evidence suggests
                      that the deterioration of the neuronal epigenetic landscape
                      contributes to brain dysfunction during aging. Epigenetic
                      aging of neurons may, however, be malleable. Recent reports
                      have shown age-related epigenetic changes in neurons to be
                      reversible and targetable by rejuvenation strategies that
                      can restore brain function during aging. This review
                      discusses the current evidence that identifies neuronal
                      epigenetic aging as a driver of cognitive decline and a
                      promising target of brain rejuvenation strategies, and it
                      highlights potential approaches for the specific
                      manipulation of the aging neuronal epigenome to restore a
                      youthful epigenetic state in the brain.},
      subtyp        = {Review Article},
      keywords     = {Humans / Brain: metabolism / Epigenesis, Genetic / Animals
                      / Neurons: metabolism / Aging: genetics / Epigenome /
                      Rejuvenation: physiology / Cognitive Dysfunction: genetics /
                      Cognitive Dysfunction: metabolism / Cognitive Decline
                      (Other) / Epigenetic Rejuvenation (Other) / Epigenome
                      Editing (Other) / Neuron Aging (Other) / Neuronal Epigenome
                      (Other)},
      cin          = {AG Toda ; AG Toda},
      ddc          = {570},
      cid          = {I:(DE-2719)1710014},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39009672},
      pmc          = {pmc:PMC11329789},
      doi          = {10.1038/s44318-024-00148-8},
      url          = {https://pub.dzne.de/record/271346},
}