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001     271346
005     20240901004648.0
024 7 _ |a 10.1038/s44318-024-00148-8
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024 7 _ |a 1460-2075
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037 _ _ |a DZNE-2024-01047
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Zocher, Sara
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245 _ _ |a Targeting neuronal epigenomes for brain rejuvenation.
260 _ _ |a Hoboken, NJ [u.a.]
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520 _ _ |a Aging is associated with a progressive decline of brain function, and the underlying causes and possible interventions to prevent this cognitive decline have been the focus of intense investigation. The maintenance of neuronal function over the lifespan requires proper epigenetic regulation, and accumulating evidence suggests that the deterioration of the neuronal epigenetic landscape contributes to brain dysfunction during aging. Epigenetic aging of neurons may, however, be malleable. Recent reports have shown age-related epigenetic changes in neurons to be reversible and targetable by rejuvenation strategies that can restore brain function during aging. This review discusses the current evidence that identifies neuronal epigenetic aging as a driver of cognitive decline and a promising target of brain rejuvenation strategies, and it highlights potential approaches for the specific manipulation of the aging neuronal epigenome to restore a youthful epigenetic state in the brain.
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650 _ 7 |a Cognitive Decline
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650 _ 7 |a Epigenetic Rejuvenation
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650 _ 7 |a Epigenome Editing
|2 Other
650 _ 7 |a Neuron Aging
|2 Other
650 _ 7 |a Neuronal Epigenome
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Brain: metabolism
|2 MeSH
650 _ 2 |a Epigenesis, Genetic
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Neurons: metabolism
|2 MeSH
650 _ 2 |a Aging: genetics
|2 MeSH
650 _ 2 |a Epigenome
|2 MeSH
650 _ 2 |a Rejuvenation: physiology
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: genetics
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: metabolism
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773 _ _ |a 10.1038/s44318-024-00148-8
|g Vol. 43, no. 16, p. 3312 - 3326
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|t The EMBO journal
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856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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