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@ARTICLE{Andac:272137,
      author       = {Andac, Safa and Stolle, Francie and Bernard, Matthieu and
                      Al-Nosairy, Khaldoon O and Wolbers, Thomas and Hoffmann,
                      Michael B},
      title        = {{N}avigation performance in glaucoma: virtual-reality-based
                      assessment of path integration.},
      journal      = {Scientific reports},
      volume       = {14},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DZNE-2024-01132},
      pages        = {21320},
      year         = {2024},
      abstract     = {Navigation is essential for moving between locations in our
                      daily lives. We investigated the relationship between visual
                      impairment in glaucoma and path-integration-based
                      navigation. Fourteen glaucoma and 15 controls underwent
                      ophthalmological examination (including visual acuity
                      (logMAR), visual field sensitivity (MD: mean deviation from
                      matched reference cohort), and peripapillary retinal nerve
                      fiber layer (pRNFL)). Both groups navigated physically in
                      virtual reality (VR) environments during daylight and dawn
                      conditions. Briefly, the participants traversed a path
                      marked by three targets, subsequently pointing back to the
                      path's origin. Outcome measures included (i) travel-time,
                      (ii) pointing-time, and (iii) Euclidian-distance error
                      between indicated and starting position. Robust linear
                      regression was conducted between visual function outcomes of
                      the better eye and VR outcome measures. Glaucoma patients
                      showed increase in travel-time (by 8.2 ± 1.7 s; p = 0.002)
                      and in pointing-time (by 5.3 ± 1.6 s; p = 0.016).
                      Predictors were MD for all outcome measures (p < 0.01) and
                      pRNFL for travel-time (p < 0.01). The results suggest that
                      the effect of glaucoma on the elapsed time depends on
                      disease progression, i.e. people with stronger visual
                      impairment need more time. This uncertainty during everyday
                      navigation tasks may adversely affect their quality of
                      life.},
      keywords     = {Humans / Female / Male / Virtual Reality / Glaucoma:
                      physiopathology / Visual Acuity: physiology / Middle Aged /
                      Visual Fields: physiology / Aged / Spatial Navigation:
                      physiology / Case-Control Studies / Glaucoma (Other) /
                      Navigation (Other) / Path integration (Other) / Virtual
                      reality (Other) / Visual field (Other)},
      cin          = {AG Wolbers},
      ddc          = {600},
      cid          = {I:(DE-2719)1310002},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11393326},
      pubmed       = {pmid:39266690},
      doi          = {10.1038/s41598-024-72040-8},
      url          = {https://pub.dzne.de/record/272137},
}