Journal Article

DZNE-2024-01132

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Navigation performance in glaucoma: virtual-reality-based assessment of path integration.

Andac, S.Extern* ; Stolle, F.Extern* ; Bernard, M.DZNE* ; Al-Nosairy, K. O. ; Wolbers, T.DZNE* ; Hoffmann, M. B.

2024
Macmillan Publishers Limited, part of Springer Nature [London]

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Please use a persistent id in citations: doi:10.1038/s41598-024-72040-8

Abstract: Navigation is essential for moving between locations in our daily lives. We investigated the relationship between visual impairment in glaucoma and path-integration-based navigation. Fourteen glaucoma and 15 controls underwent ophthalmological examination (including visual acuity (logMAR), visual field sensitivity (MD: mean deviation from matched reference cohort), and peripapillary retinal nerve fiber layer (pRNFL)). Both groups navigated physically in virtual reality (VR) environments during daylight and dawn conditions. Briefly, the participants traversed a path marked by three targets, subsequently pointing back to the path's origin. Outcome measures included (i) travel-time, (ii) pointing-time, and (iii) Euclidian-distance error between indicated and starting position. Robust linear regression was conducted between visual function outcomes of the better eye and VR outcome measures. Glaucoma patients showed increase in travel-time (by 8.2 ± 1.7 s; p = 0.002) and in pointing-time (by 5.3 ± 1.6 s; p = 0.016). Predictors were MD for all outcome measures (p < 0.01) and pRNFL for travel-time (p < 0.01). The results suggest that the effect of glaucoma on the elapsed time depends on disease progression, i.e. people with stronger visual impairment need more time. This uncertainty during everyday navigation tasks may adversely affect their quality of life.

Keyword(s): Humans (MeSH) ; Female (MeSH) ; Male (MeSH) ; Virtual Reality (MeSH) ; Glaucoma: physiopathology (MeSH) ; Visual Acuity: physiology (MeSH) ; Middle Aged (MeSH) ; Visual Fields: physiology (MeSH) ; Aged (MeSH) ; Spatial Navigation: physiology (MeSH) ; Case-Control Studies (MeSH) ; Glaucoma ; Navigation ; Path integration ; Virtual reality ; Visual field

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Contributing Institute(s):

1. Aging, Cognition and Technology (AG Wolbers)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

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