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000272495 037__ $$aDZNE-2024-01171
000272495 041__ $$aEnglish
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000272495 1001_ $$aMüller, Julia$$b0
000272495 245__ $$aDifferential Psychological Treatment Effects in Patients With Late-Life Depression and a History of Childhood Maltreatment.
000272495 260__ $$bOvid$$c2024
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000272495 520__ $$aThis is the first interventional study to assess the impact of childhood maltreatment (CM) on psychological treatment outcomes in patients with late-life depression (LLD).This is a secondary analysis of a multicenter, randomized controlled trial with 251 participants aged ≥60 years with moderate to severe depression. Participants were randomly assigned to cognitive behavioral therapy for late life depression (LLD-CBT) or to a supportive intervention (SUI). Treatment outcomes were measured by changes in the Geriatric Depression Scale (GDS).In the intention-to-treat sample (n = 229), both LLD-CBT (n = 115) and SUI (n = 114) significantly reduced depressive symptoms in patients with CM, with large effects at post-treatment (d = 0.95 [95% CI: 0.65 to 1.25] in LLD-CBT; d = 0.82 [95% CI: 0.52 to 1.12] in SUI). A significant treatment group*CM interaction (F(1,201.31) = 4.71; p = .031) indicated greater depressive symptom reduction in LLD-CBT compared to SUI at week 5 and post-treatment for patients without CM, but not at 6-month follow-up. Across both treatments, higher severity of the CM subtype 'physical neglect' was associated with a smaller depressive symptom reduction (F(1,207.16) = 5.37; p = .021).Specific and non-specific psychotherapy effectively reduced depressive symptoms in older individuals with depression and early trauma. For patients without early trauma, LLD-CBT may be preferable over SUI. Considering early trauma subtypes may contribute to develop personalized treatment approaches.
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000272495 650_7 $$2Other$$achildhood maltreatment
000272495 650_7 $$2Other$$acognitive behavioral therapy
000272495 650_7 $$2Other$$aearly trauma
000272495 650_7 $$2Other$$alate-life depression
000272495 650_7 $$2Other$$anon-specific supportive intervention
000272495 650_7 $$2Other$$aolder age
000272495 650_2 $$2MeSH$$aHumans
000272495 650_2 $$2MeSH$$aMale
000272495 650_2 $$2MeSH$$aFemale
000272495 650_2 $$2MeSH$$aAged
000272495 650_2 $$2MeSH$$aCognitive Behavioral Therapy: methods
000272495 650_2 $$2MeSH$$aMiddle Aged
000272495 650_2 $$2MeSH$$aDepression: therapy
000272495 650_2 $$2MeSH$$aTreatment Outcome
000272495 650_2 $$2MeSH$$aAdult Survivors of Child Abuse: psychology
000272495 650_2 $$2MeSH$$aChild Abuse: psychology
000272495 650_2 $$2MeSH$$aAged, 80 and over
000272495 7001_ $$aElsaesser, Moritz$$b1
000272495 7001_ $$aMüller, Wiebke$$b2
000272495 7001_ $$aHellmich, Martin$$b3
000272495 7001_ $$aHammen, Magdalena$$b4
000272495 7001_ $$aZehender, Nadine$$b5
000272495 7001_ $$aRiedel-Heller, Steffi$$b6
000272495 7001_ $$aBewernick, Bettina H$$b7
000272495 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b8$$udzne
000272495 7001_ $$aFrölich, Lutz$$b9
000272495 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b10$$udzne
000272495 7001_ $$aDafsari, Forugh S$$b11
000272495 7001_ $$aDomschke, Katharina$$b12
000272495 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b13$$udzne
000272495 7001_ $$aHautzinger, Martin$$b14
000272495 7001_ $$aSchramm, Elisabeth$$b15
000272495 773__ $$0PERI:(DE-600)1474415-6$$a10.1016/j.jagp.2024.05.006$$gVol. 32, no. 11, p. 1325 - 1336$$n11$$p1325 - 1336$$tAmerican journal of geriatric psychiatry$$v32$$x1064-7481$$y2024
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