Journal Article

DZNE-2024-01171

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Differential Psychological Treatment Effects in Patients With Late-Life Depression and a History of Childhood Maltreatment.

Müller, J. ; Elsaesser, M. ; Müller, W. ; Hellmich, M. ; Hammen, M. ; Zehender, N. ; Riedel-Heller, S. ; Bewernick, B. H. ; Wagner, M.Extern* ; Frölich, L. ; Peters, O.DZNE* ; Dafsari, F. S. ; Domschke, K. ; Jessen, F.Extern* ; Hautzinger, M. ; Schramm, E.

2024
Ovid

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Please use a persistent id in citations: doi:10.1016/j.jagp.2024.05.006

Abstract: This is the first interventional study to assess the impact of childhood maltreatment (CM) on psychological treatment outcomes in patients with late-life depression (LLD).This is a secondary analysis of a multicenter, randomized controlled trial with 251 participants aged ≥60 years with moderate to severe depression. Participants were randomly assigned to cognitive behavioral therapy for late life depression (LLD-CBT) or to a supportive intervention (SUI). Treatment outcomes were measured by changes in the Geriatric Depression Scale (GDS).In the intention-to-treat sample (n = 229), both LLD-CBT (n = 115) and SUI (n = 114) significantly reduced depressive symptoms in patients with CM, with large effects at post-treatment (d = 0.95 [95% CI: 0.65 to 1.25] in LLD-CBT; d = 0.82 [95% CI: 0.52 to 1.12] in SUI). A significant treatment group*CM interaction (F(1,201.31) = 4.71; p = .031) indicated greater depressive symptom reduction in LLD-CBT compared to SUI at week 5 and post-treatment for patients without CM, but not at 6-month follow-up. Across both treatments, higher severity of the CM subtype 'physical neglect' was associated with a smaller depressive symptom reduction (F(1,207.16) = 5.37; p = .021).Specific and non-specific psychotherapy effectively reduced depressive symptoms in older individuals with depression and early trauma. For patients without early trauma, LLD-CBT may be preferable over SUI. Considering early trauma subtypes may contribute to develop personalized treatment approaches.

Keyword(s): Humans (MeSH) ; Male (MeSH) ; Female (MeSH) ; Aged (MeSH) ; Cognitive Behavioral Therapy: methods (MeSH) ; Middle Aged (MeSH) ; Depression: therapy (MeSH) ; Treatment Outcome (MeSH) ; Adult Survivors of Child Abuse: psychology (MeSH) ; Child Abuse: psychology (MeSH) ; Aged, 80 and over (MeSH) ; childhood maltreatment ; cognitive behavioral therapy ; early trauma ; late-life depression ; non-specific supportive intervention ; older age

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Contributing Institute(s):

1. Biomarker-Assisted Early Detection of Dementias (AG Peters)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Social and Behavioral Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

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