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@ARTICLE{Mller:272495,
      author       = {Müller, Julia and Elsaesser, Moritz and Müller, Wiebke
                      and Hellmich, Martin and Hammen, Magdalena and Zehender,
                      Nadine and Riedel-Heller, Steffi and Bewernick, Bettina H
                      and Wagner, Michael and Frölich, Lutz and Peters, Oliver
                      and Dafsari, Forugh S and Domschke, Katharina and Jessen,
                      Frank and Hautzinger, Martin and Schramm, Elisabeth},
      title        = {{D}ifferential {P}sychological {T}reatment {E}ffects in
                      {P}atients {W}ith {L}ate-{L}ife {D}epression and a {H}istory
                      of {C}hildhood {M}altreatment.},
      journal      = {American journal of geriatric psychiatry},
      volume       = {32},
      number       = {11},
      issn         = {1064-7481},
      publisher    = {Ovid},
      reportid     = {DZNE-2024-01171},
      pages        = {1325 - 1336},
      year         = {2024},
      abstract     = {This is the first interventional study to assess the impact
                      of childhood maltreatment (CM) on psychological treatment
                      outcomes in patients with late-life depression (LLD).This is
                      a secondary analysis of a multicenter, randomized controlled
                      trial with 251 participants aged ≥60 years with moderate
                      to severe depression. Participants were randomly assigned to
                      cognitive behavioral therapy for late life depression
                      (LLD-CBT) or to a supportive intervention (SUI). Treatment
                      outcomes were measured by changes in the Geriatric
                      Depression Scale (GDS).In the intention-to-treat sample (n =
                      229), both LLD-CBT (n = 115) and SUI (n = 114) significantly
                      reduced depressive symptoms in patients with CM, with large
                      effects at post-treatment (d = 0.95 $[95\%$ CI: 0.65 to
                      1.25] in LLD-CBT; d = 0.82 $[95\%$ CI: 0.52 to 1.12] in
                      SUI). A significant treatment group*CM interaction
                      (F(1,201.31) = 4.71; p = .031) indicated greater depressive
                      symptom reduction in LLD-CBT compared to SUI at week 5 and
                      post-treatment for patients without CM, but not at 6-month
                      follow-up. Across both treatments, higher severity of the CM
                      subtype 'physical neglect' was associated with a smaller
                      depressive symptom reduction (F(1,207.16) = 5.37; p =
                      .021).Specific and non-specific psychotherapy effectively
                      reduced depressive symptoms in older individuals with
                      depression and early trauma. For patients without early
                      trauma, LLD-CBT may be preferable over SUI. Considering
                      early trauma subtypes may contribute to develop personalized
                      treatment approaches.},
      keywords     = {Humans / Male / Female / Aged / Cognitive Behavioral
                      Therapy: methods / Middle Aged / Depression: therapy /
                      Treatment Outcome / Adult Survivors of Child Abuse:
                      psychology / Child Abuse: psychology / Aged, 80 and over /
                      childhood maltreatment (Other) / cognitive behavioral
                      therapy (Other) / early trauma (Other) / late-life
                      depression (Other) / non-specific supportive intervention
                      (Other) / older age (Other)},
      cin          = {AG Peters},
      ddc          = {610},
      cid          = {I:(DE-2719)5000000},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38824050},
      doi          = {10.1016/j.jagp.2024.05.006},
      url          = {https://pub.dzne.de/record/272495},
}